- Piedmont Triad International Airport (IATA: GSO),  is about a 20 minute drive (20 miles) east of downtown between Winston-Salem and Greensboro.
- Smith Reynolds Airport (IATA: INT),  located 3 miles northeast of Winston-Salem is available for charters and general aviation.
An Amtrak station with shuttle service to Winston-Salem is located in nearby Greensboro.
Winston-Salem is easily accessible by car via Interstate 40, Business Interstate 40, Interstate 77, Interstate 85 and U.S. Highway 52 (Future Interstate 73/74).
Greyhound Bus, +1 336-724-1429, 100 W 5th St, .
Winston-Salem Transit Authority  provides local bus service for $1 a ride, $0.50 for elderly and disabled, children shorter than the farebox and accompanied by an adult ride free; transfers are free.
- Blue Bird Cab Co, +1 336-722-7121
- Lott's Taxi Service, +1 336-720-9797
- Willard's Cab Co, +1 336-725-2227
- West End Historic District (Winston-Salem's Front Porch), W. Fourth St. and Brookstown Ave. (North at Broad St. exit on Business 40 in downtown Winston-Salem, then left onto W. Fourth St. until at Brookstown). Most Shopping 10AM - 6PM; Most Dining 11AM - 9PM. From its beginnings as a regional spa resort and an exclusive community of wealthy tobacco and textile families, Winston-Salem's West End is now a dining and shopping center for the city and a perfect place to explore pedestrian charms. Built around one of the first electric streetcar lines in the country, the West End boasted "Millionaires' Row," where the Reynolds and Hanes families kept homes bought with manufacturing fortunes. Featuring homes built between 1890 and 1930, the neighborhood is known both for its hospitality and the area's largest and most-varied concentration of front porch designs. No admission fee.
- Historic Bethabara Park, 2147 Bethabara Road. The first NC Moravians settled here in 1753, the founding site of Forsyth County. The Park features costumed guides leading visitors through a 1788 furnished church. Additionally, you can view two period buildings, a restored French/Indian War fort and restored medicinal garden. Greenways and path traverse the 175-acre preserve.
- The Charlotte and Philip Hanes Art Gallery at the Scales Fine Arts Center, 1834 Wake Forest Road, ☎ . In 1991, the Scales Fine Arts Center of Wake Forest University, dedicated it’s gallery to Philip Hanes and his wife, Charlotte, in recognition of their contributions to the arts. The Gallery has an ongoing schedule of diverse exhibits and has housed showings that included works of Pablo Picasso and Andy Warhol, among others.
- Diggs Museum, 601 South Martin Luther King Drive. Named for James Thackeray “T” Diggs, Jr., a 1934 graduate of Winston-Salem State University, painter and art professor for 40 years. Exhibiting one of NC’s largest displays dedicated to the arts of Africa and African Diasporas, it also hosts musical performances, dance, drumming, artist workshops, theater productions and film screenings.
- Downtown Arts District (DADA), Sixth and Trade Streets in Downtown. An ultra-hip area of downtown, DADA, is an eclectic collection of working studios, galleries, shops and restaurants. Just a block from the Benton Convention Center, this exciting neighborhood is easy to find. Come and explore this inspiring world of jewelers, fiber artists, wood and metal workers, antique dealers and sculptors.
- Delta Arts Center, 2611 New Walkertown Road, ☎ . Opened in 1982 by the local alumnae chapter of Delta Sigma Theta Society, Inc., to enrich the community by stimulating interest in American arts and humanities, the center emphasizes the contributions of African Americans. Delta Arts Center hosts exhibitions, lectures, performances and special programming in visual arts, music, literature, history and folk arts.
- Old Salem Museums and Gardens, 900 Old Salem Rd, ☎ . Old Salem Museums & Gardens is America’s most comprehensive history attraction. The Historic Town of Salem and the Museum of Early Southern Decorative Arts (MESDA) engage visitors in an educational and memorable historical experience about those who lived and worked in the early South.
- Children's Museum of Winston-Salem, 390 South Liberty Street, ☎ . A compelling destination for the community to play and learn by experiencing literature, storytelling and the arts. Weekly programs, special events, birthday parties and field trips are just a few of the opportunities available at this gallery of discovery designed for children birth to 10 and their families.
- Reynolda House Museum of American Art, 2250 Reynolda Road, toll-free: . Experience Winston-Salem’s golden era. The historic home of tobacco baron R.J. Reynolds and wife, Katherine will charm you with a collection of American masterpieces ranging from the colonial period to the present, vintage clothing, original furnishings and family memorabilia in the restored home. The new wing offers exhibitions and a visitor center.
- SciWorks, 400 West Hanes Mill Rd, ☎ . With a state-of-the-art Planetarium, 15-acre Environmental Park and 45,000 square feet of exhibits, learning about science is fun at SciWorks. See a planetarium show, visit barnyard animals or come face-to-face with a NC river otter! At SciWorks, there are interactive, hands-on special exhibits and programs for all ages to enjoy.
- The Southeastern Center for Contemporary Art, 750 Marguerite Drive, ☎ . Consistently featuring the best of today’s regional and national contemporary artists, SECCA fosters creative excellence through changing exhibitions. Past exhibits have featured artists such as William Wegman and Yoko Ono. The modern galleries are housed within the elegant stateliness of a Tudor-style house that was once the estate of industrialist James G. Hanes.
- Wake Forest University Museum of Anthropology, 1834 Wake Forest Road, ☎ . The Museum of Anthropology (MOA) at Wake Forest University is North Carolina’s only museum dedicated to the study of global cultures. The museum’s permanent exhibits display objects from the Americas, Africa, Asia and Oceania. In 2007, changing exhibits will focus on ancient Greece, the Lakota Sioux and New Guinea.
- Winston-Salem Dash, Peters Creek Parkway. Downtown. Enjoy Advanced Single-A minor league baseball at the beautiful new BB&T ballpark that opened in the Spring of 2010. Season: April-September. An affiliate of the Chicago White Sox. It is a great source of family entertainment in fun in the downtown area. $7-$13.
- University of North Carolina School of the Arts, 1533 South Main St. Downtown. There is almost always a production or performance happening at this prestigious Fine Arts university.
- Wake Forest University 
- Winston-Salem State University 
- Salem College 
- University of North Carolina School of the Arts 
Hanes Mall, the largest shopping mall in North Carolina, and one of the largest in the southeastern United States. The area surrounding the mall along Stratford Road, Silas Creek Parkway, and Hanes Mall Boulevard has become the city's largest shopping district.
Other major shopping areas are found along Peters Creek Parkway (home of Marketplace Mall), University Parkway, Jonestown Road, North Point Boulevard, Reynolda Road, and Robinhood Road.
- Little Richard's Bar-B-Que, 4885 Country Club Rd, ☎ .
- La Carreta
- Upper Crust Pizza, 1816 Silas Creek Pkwy, ☎ . Offering a variety of pizza, lunch buffet, wings, subs, Italian specials, kids menu. Eat-in, take-out or delivery. Open late.
- Mellow Mushroom, 314 West 4th St, ☎ .
- Village Tavern There are two Village Taverns in Winston-Salem. The bigger one is located on Hanes Mall Blvd. near the mall and smaller, original is located on Reynolda near Wake Forest. Both have great food, but you may want to choose depending on the atmosphere you are looking for. They both are very busy on weekends, so make sure you plan for a little bit of a wait.
- The Loop
- The Carving Board
- Ishi Probably the most popular spot in town to go for sushi. Not the best though.
- Sakura Right down the street from Ishi, better quality food.
- Sweet Potatoes
- Botta Bing
- Mary's Of Course The best brunch in Winston-Salem!
- Cat's Corner
- West End Cafe
- Bistro 421
- Downtown Thai
- Fourth Street Filling Station
- Hutch and Harris
- Milner's American Southern
- Mozelle's Fresh Southern Bistro
- Noble's Grille
- Ryan's Steakhouse
- Sixth and Vine
Burke St Pub is one of the best pubs in town. Very cheap drink specials and friendly staff.
Finnegan's Wake and West End Opera House are also local institutions.
- Quality Inn Coliseum, 531 Akron Drive. Check-in: 3PM, check-out: 12AM. $65-$130.
- Comfort Suites Winston-Salem, 200 Capital Lodging Court, ☎ . Complimentary continental breakfast, wireless internet, on-site laundry, seasonal outdoor pool and fitness and business center.
- Embassy Suites, 460 North Cherry St, ☎ . Check-in: 3PM, check-out: Noon. $169.
- Marriott Winston-Salem, 425 North Cherry Street.
- Microtel Inn Winston-Salem, NC, 100 Capital Lodging Court, Winston-Salem, NC 27103, ☎ .
- Winston-Salem Visitor Center, 200 Brookstown Avenue, Winston-Salem, North Carolina 27101, Main Telephone: +1 336 728-4200 (Toll Free: +1-866-728-4200; Fax: +1 336 721-2202; email: email@example.com. The Visitor Center is open 8:30AM-5PM daily, except New Year's Day, Easter Sunday, Thanksgiving Day and Christmas Day.
Winston-Salem is generally safe. Like most cities in the world, there are certain areas that may not be the safest at night, particularly in the eastern half of the city. Though its downtown was once a seedy, shady region, it has been thoroughly cleaned up, especially Fourth Street. Most populated areas in the city, such as shopping and dining, are very safe. Normal precautions should be taken.
|Routes through Winston-Salem|
|Asheville ← Statesville ←||W E||→ Greensboro → Chapel Hill|
|END ←||W E||→ High Point → Asheboro|
|Bluefield ← King ←||N S||→ Lexington → Florence|