There's more than one place called Santa Fe.
- Santa Fe (city, Argentina) - capital city of Santa Fe (province, Argentina)
- Santa Fe (province, Argentina) - a province in Pampas region
- Santa Fe (Galapagos) - an island in the Galapagos Islands
- Santa Fe - a district of Mexico City
- Santa Fe (Panama) - a small town in Veraguas province
- Santa Fe (Florida) - a town in Florida
- Santa Fe (New Mexico) - capital of the state of New Mexico
- Santa Fe Trail - historic route between Missouri and the Southwest, treated here as an itinerary
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