File:Serpin mechanism (S to R).png

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Summary

Description
English: The inhibitory mechanism of serpins involved a large conformation change.The serpin (white) first binds a protease (grey) with the reactive centre loop (blue). When cleaved by the protease, this loop rapidly inserts into the A-sheet (light blue), deforming and inhibiting the protease. (PDB: 1K9O​, 1EZX​)
Date
Source Own work
Author Thomas Shafee

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inception

13 December 2015

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Date/TimeThumbnailDimensionsUserComment
current23:04, 19 March 2016Thumbnail for version as of 23:04, 19 March 20163,000 × 3,000 (2.83 MB)Evolution and evolvabilityColour tweaks
09:55, 22 December 2015Thumbnail for version as of 09:55, 22 December 20151,800 × 1,868 (1.13 MB)Evolution and evolvabilityHigher resolution and darker grey for protease
00:36, 20 December 2015Thumbnail for version as of 00:36, 20 December 20151,083 × 1,125 (498 KB)Evolution and evolvabilityblue arrow (inkeeping with Serpin mechanism.png scheme)
11:52, 13 December 2015Thumbnail for version as of 11:52, 13 December 20151,083 × 1,125 (496 KB)Evolution and evolvabilityA-sheet colour
11:33, 13 December 2015Thumbnail for version as of 11:33, 13 December 20151,150 × 1,111 (462 KB)Evolution and evolvabilityCross-wiki upload from en.wikipedia.org

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