- Chacaltaya & Huayna Potosí — Bolivia's premiere ski resort, located right by the country's highest mountain
- Madidi National Park
- Sajama National Park
- Salar de Uyuni
- Yungas Road (Camino de la Muerte) — infamous for being the most dangerous road in the world, in the Yungas Region, the notoriety of this road from La Paz to Coroico has turned it into a popular destination for international tourists, especially bicyclists. Bolivia has finally finished the alternate paved route, so there is far less traffic on this road, and is at least a little safer for that.
- One of the highlights of this region is the Salar de Uyuni: 200 square miles of flat dazzling white salt at an altitude of 3700 metres. There are many tours of this salt lake from Uyuni - or for a four-day tour choose the one from Tupiza near the Argentine border. There are many fascinating islands on the lake with giant cactii growing everywhere.
- Another highlight in the Bolivian altiplano are the highland lagunas in the southeast near the border to Chile. Most known is the Laguna Colorada and also the Laguna Verde as well as the Árbol de Piedra.
During the Bolivian winter time (in June and July) the temperatures can drop really low so bring good winter clothes and a sleeping bag suitable for temperatures bellow 0 degrees.