- 1 Medellín - Considered by many as the best city in Colombia. Medellín is home to the famous yearly "Flower Festival" in August and the first (and still only) metro system in the country: "Metro de Medellín". Home City of Juanes, Fernando Botero and René Higuita. The metropolitan area is surrounded by many small towns which have become virtual suburbs of the city. These include Envigado, Itaguí, Sabaneta and Caldas (south); Bello, Copacabana and Girardota (north). The spread of the city east and west is limited by topography.
- 2 Apartadó town and municipality in Urabá subregion
- 3 Capurganá even though outside of Antioquia it is easier to get there from Medellín by plane or by boat from Turbo. A great, quiet beach destination in the Atlantic, near Panamá.
- Granada is a town at East of Antioquia. It's a zone of water, cool weather, but hot people. In this place you can say "Home, sweet home". It was the cradle of bishop Tiberio de J. Salazar y Herrera.
- 4 Guatape
- 5 Jardín is a beautiful little town 2 hours south of Medellín, with incredible tourist attractions: a gorgeous main plaza, distinctive local architecture amd many country-side activities. Look for the locally produced rainbow trout and coffee to please your senses.
- 6 Marinilla , Rionegro, Guarne and La Ceja these are small towns east of Medellín and a popular day trip destination.
- 7 Necoclí
- 8 Santa Fe de Antioquia , the oldest capital. A quaint colonial town, 50 km northwest of Medellín.
- 9 Turbo - The small city on the Caribbean coast itself doesn't have a lot to offer, and it's primary interest to travellers is its role as the place to get a boat to Capurganá, from where it is possible to get a boat to Puerto Obaldia in Panama.
- 10 Caucasia (Antioquia)
- 11 El Bagre
- 12 Remedios (Antioquia)
There are 6 operational airports with daily commercial flights in Antioquia.
- Olaya Herrera (EOH IATA) in Medellín.
- Antonio Roldán Betancourt (APO IATA), Formerly Los Cedros. Located in the municipality of Carepa. Serves Apartadó and the Urabá region in the Atlantic side of the department. It is also the heart of the banana growing region. Four airlines connect this airport to Medellín EOH.
All located in the North of the department, area with heavy gold mining. Flights originate mostly from Olaya Herrera Airport in Medellín.
- Juan H. White Airport (CAQ IATA) in Caucasia.
- El Tomin (EBG IATA), in the municipality of El Bagre.
- Otú Airport (OTU IATA) in the municipality of Remedios.
In Medellín you can get around by taxi bus or metro. The metro runs largely along the north-south axis of the city.
By cable car
Antioquia is mountainous hence Cable Cars have sprawled in the last 2 decades and are becoming popular for both commuting and tourist transportation. You can ride the Metrocables in Medellín which are additional lines of the Metro system or the countryside cable-cars in many small towns in Antioquia: Jardín, Jericó, Sopetrán, San Andrés de Cuerquia, etc.
- . Also by rental cars and trucks.
- San Jeronimo, Sopetran and Santa Fe de Antioquia - Going north-west from downtown Medellín, you arrive at the longest and newest South American tunnel: 4.7 km. After you pass through that tunnel, you start descending mountains and a few minutes later, you are in San Jeronimo, Antioquia. Cruise it on motorcycle, the fun way, don't be scared because its an awesome experience! Weather here is 25 degrees during the whole year. Very close you will find Sopetran, the Antioquias fruits lovely capital. Finally, you get to Santa Fe de Antioquia, one of the five colonial destinations in Colombia, and the way to the Caribbean. This road will take you to Turbo and to the Panama frontier line - the road is more safe now and is not frequented by guerrillas and paramilitaries anymore.
- Frontino further to the west, is a nice town.
The Holy Week in many towns of Antioquia is colorful and passionate.
Act as you would in any large, and potentially unsafe metropolitan area such as Chicago or São Paulo.
- As of 2010 there are plenty of landmines in the countryside, making much of Antioquia out of bounds for tourists.
- There are guerrillas of the FARC and ELN active in many rural locations of this department. They will kidnapp for ransom and hold little symphaty for tourists.
- Due to the high amounts of violence in the region the Australian Foreign Office advises against travelling to Antioquia. This travel warning was issued in December of 2010 
- Don't buy drugs, or even ask about them.
- Do not get in a taxi if there is someone other than the driver in it
- Avoid downtown and Parque Berrio at night.
- Avoid walking around like you're lost, as this may be noticed by the wrong sort of people; if you are lost step in to a cafe or "tienda", restaurant, ask someone there.
- It's best to use ATMs located in Exito, Carrefour, Carulla or Pomona (supermarkets in the Medellín area) or to use the ones inside the banks,
- Always be aware that you might be followed from ATMs and banks.