Long-distance bus travel can be an interesting, inexpensive, and convenient way to see Mexico. Several other small companies also provide bus travel as well.

Understand

Mexico has a world-class bus system, and service efficiency is on par with trains in Europe and East Asia. The route density of Mexican nationwide bus system surpasses the counterparts in the United States, Europe, and East Asia.

Buses are without a doubt the backbone of personal intercity transport in Mexico because as of 2024 only 40% of Mexicans own a car, there is no high-speed rail in Mexico, trains mostly serve cargo and tourism purposes, and historically, domestic air travel was dominated by Aeromexico and as a result was very expensive.

Chances are, you will meet a lot of locals, traveling by bus. Rates by distance are generally comparable to those of Greyhound in the U.S. or long-distance buses in Europe and East Asia. However, there are more departures, and unlike its American, European and East Asian counterparts, also serve smaller villages.

For going from one city to another, the apps of CheckMyBus and Busbud show the departure times and the according bus company.

If traveling by bus, be sure to take the express (first class) buses (directo, sin escalas, primera clase), if available. First class buses are usually direct routes and are the best option for most. These buses are comfortable, have washrooms/toilets and will generally show movies, which may or may not be in English with Spanish subtitles (or vice versa). Others may even offer a drink and a little snack. First class buses travel over longer distances between cities use toll freeways where available. They may make scheduled stops (semi-directo) at specific bus stations en route otherwise they make no stops en-route (sin escalas).

Other buses such as the second class (economico, ordinario, local) buses may be very similar to first class only they travel along secondary highways through cities, towns and villages and stop anywhere along the road on request. Second class bus routes are typically shorter and will take considerably longer to travel over longer distances (such as from Cancun to Mexico City) with multiple stops and multiple transfers, it is not worth the few pesos saved over first class buses. They are fine for more local travel, such as between Cancun and Playa del Carmen or to somewhere along the highway in between. In other places they may be more frequent and more available than first class such as going to Zempoala (town) from Veracruz (city). Some of the second class buses may even be chicken buses (polleros) in rural, off the beaten track, places.

Executive (Ejecutivo) and Luxury (Lujo) lines cost about 60% more than first class, are faster, usually have larger seats, and they have less frequent departures; they rival flying business class on a plane and are a good option for elderly or business travelers or overnight travel in lieu of a night's stay at a hotel (or hostel).

When acquiring tickets for the bus, the local custom is that the passenger comes to the terminal and buys the ticket for next available bus going to the desired destination with first and deluxe class buses unless it is during busy travel times such as Easter and Christmas. During busy travel times tickets can be booked one or two days in advance online or at the station. With second class buses, tickets can be purchased at the station within 2 hours of a departure, no advance reservations prior, at the beginning of a route or the fare paid to the driver if picked up from alongside of the road.

With the advent of NAFTA, some bus companies are now offering service from cities in several US states.

Major companies

• ABC (Autobuses de Baja California). Bus services up and down Hwy 1 in the Baja California Peninsula in both Baja California Norte y Sur states and along Hwy 2/2D to western Sonora (updated Oct 2016)
• ADO (Autobuses Del Oriente), ☏ +52 55 5133-5133, toll-free: 01 800-009-9090. They operate the ADO, ADO GL, AU (Autobus Unidos), OCC (Omnibus Cristobal Colon), Platino, Texcoco, Diamante, Estrella de Oro, Cuenca and Pluss bus lines and the ClickBus booking site (formerly Boletotal & Ticketbus). They are a major bus company in the eastern and southeastern part of the country towards the Guatemalan border in the states of Guerrero, Puebla, Veracruz, Chiapas, Tamaulipas, Tabasco, and the Yucatan Peninsula (Yucatan, Quintana Roo and Campeche). Travel towards Guatemala via Tapachula or Tuxtla Guttierrez; to Belize through Chetumal and the United States border through Matamoros. They only offer cross border buses to Belize City from Cancun and Merida via Chetumal. 
• Autobuses Coordinados de Nayrit (ACN), toll-free: 01800 026-73-73. They serve mainly in the western and northwestern states of Baja California Norte, Jalisco, Michocoan, Nayrit, Sinaloa and Sonora in Mexico and California (historically 'Alta California') in the U.S. (updated Jul 2017)
• Autovias, toll-free: 01 800-622-22-22. serving Colima, Guerrero, Guanajuato, Jalisco, Michoacan, Mexico DF, Estado Mexico and Queretaro. Other subsidiary brands include Allegra, La Linea and the Pegasso brands. (updated Aug 2017)
• Costa Line AERS, ☏ +52 55 5336-5560, toll-free: 01 800-0037-635. Serves mainly in Mexico state, Morelos and Guerrero from Mexico City. They also operate the Turistar, Futura and AMS bus lines. 
• ETN (Enlances Terrestre Nacionales), Turistar Lujo. They offer a 'deluxe' or 'executive' class seating with 2 seats on one side of the aisle and one on the opposite side with more leg room and an ability to recline into a lying position. They go to Aguascaliente, Baja California Norte, Coahuila, Chihuahua, Durango, Guanajuato, Guerrero, Hidalgo, Jalisco, Mexico, Mexico City DF, Michocoan, Morelos, Nayrit, Nuevo Leon, Oaxaca (coast), Queretaro, San Luis Potosi, Sinaloa, Sonora, Veracruz (Poza Rica, Tuxpan) and Zacatecas states 
• Grupo Estrella Blanca (White Star), ☏ +52 55 5729-0807, toll-free: 01 800-507-5500. They operate the Anahuac, Elite, TNS (Transportes Norte de Sonora), Chihuahuanese, Pacifico, TF (Tranporte Frontera), Estrella Blanca, Conexion, Rapidos de Cuauhtemoc, Valle de Guadiana and Autobus Americanos bus lines. As the largest bus company they serve much of the northern and northwestern part of the country such as Aguascaliente, Baja California Norte, Coahuila, Chihuahua, Durango, Districto Federal (DF), Guanajuato, Guerrero, Hidalgo, Jalisco, Estado de Mexico, Michoacán, Morelos, Nayarit, Queretaro, San Luis Potosi, Sinaloa, Sonora and Zacatecas states, up to the US border. They sell tickets for onward travel to the United States from the border on Greyhound Lines (and vice versa). (updated Dec 2023)
• Estrella de Oro (Gold Star), ☏ +52 55 5133-5133, toll-free: 01 800-009-9090. operates mainly between Mexico City and various places in Districto Federal (DF), Guerrero, Veracruz and Hidalgo states. They are now a subsidiary of Grupo ADO but continue to operate as a separate company and brand. 
• Estrella Roja (Red Star), ☏ +52 222 273-8300, toll-free: 01 800-712-2284. Travels mainly between Mexico City and Puebla. 
• Primera Plus (Grupo Flecha Amarilla), ☏ +52 477 710-0060, toll-free: 0800 375-75-87. Subsidiary of Grupo Flecha Amarilla which also include ETN, Turistar Lujo, Servicios Coordinados, TTUR and Flecha Amarilla (second class service) bus lines. They serve Jalisco, Michoacán, Guanajuato, Colima, Aguascalientes, Querétaro, San Luis Potosí, México,D.F., Nayarit, Estado de Mexico, Hidalgo, Guerrero and Sinaloa states 
• Grupo Flecha Roja, Aguila, ☏ +52 55 5516 5153, toll-free: 01 800 224-8452. Operates mainly between Mexico City and various places in northern part of Mexico state into Queretaro state on the Flecha Roja brand and to the southeastern part of Mexico State into Guerrero and Morelos states as Aguila. (updated Dec 2023)
• FYPSA, ☏ +52 951 516-2270. operates mainly between Districto Federal (DF), Mexico state, Oaxaca and Chiapas states. 
• Omnibus de Mexico, ☏ +52 55 5141-4300, toll-free: 01 800-765-66-36. They serve much of the central and northern part of the country such as Aguascaliente, Colima, Coahuila, Chihuahua, Durango, Guanajuato, Guerrero, Jalisco, Michocoan, Nayrit, Queretaro, San Luis Potosi, Sinaloa, Sonora, Tamaulipas, Veracruz and Zacatecas states, up to the US border. 
• Pullman de Morelos, ☏ +52 55 5545-3505, toll-free: 0800 624-03-60. Operates buses in/around Guerrero and Morelos. They operate the Ejecutivo Dorado (Golden Executive), Pullman de Lujo, Primera Clase, Primera Federal and Primera Local (2nd class). 
• Grupo Senda. They serve much of the north central part of the country such as Aguascaliente, Colima, Coahuila, Chihuahua, Durango, Guerrero, Jalisco, Michoacan, Nuevo Leon, Queretaro, San Luis Potosi, Sinaloa, Tamaulipas and Zacatecas states, up to the US border as. From the border they continue up to the southeastern and central U.S. states of Alabama, Arkansas, Georgia, Illinois, Louisiana, Mississippi, Oklahoma, North Carolina, South Carolina and Tennessee from Texas as Turimex Internacional. They also operate the and Del Norte and Coahuilenses bus lines in north central part of Mexico, south of Texas. 
• TAP, toll-free: 0800-0011-827. Operates bus more or less along the Hwy 15 corridor between Tijuana and Guadalajara and other places off of the Hwy 15 corridor in Baja California Norte, Guerrero, Jalisco, Michoacán, Nayarit, Sinaloa, Sonora, Estado de Mexico and Mexico DF. They also operate the TAP Royal bus lines from the border to Los Angeles, Phoenix, Las Vegas and Tucson in the southwestern part of the U.S. (updated Aug 2017)
• Zina Bus, Excelencia, Excelencia Plus, ☏ +52 55 5278-4721. Goes from Mexico DF to the surrounding Mexico, Guerreo and Michoacan states. The company also operate Autobus Pegasso to Guanajuato and Querétaro as well as Estado de Mexico and Michoacán. 

The above are major bus lines traversing much of the country with some crossing the border into the U.S. No bus company holds a large market share nationwide like Greyhound in the U.S. but some do have a greater market share in certain regions. There are over 200 other companies and drivers' unions operating buses not listed in the above which you will find once there or see (or add to) the specific articles of a region, city or town.