The Central Panama region includes much of Panama province and all of Colon and Cocle provinces.
- El Valle - a charming little town nestled in the second biggest inhabited volcanic caldera in the world. El Valle boasts an all-year spring-like climate, amazing biodiversity, and a wide selection of hotels and restaurants among others. Located about an hour west of Panama City.
- Pearl Islands - Archipelago de las Perlas
- Taboga - an island getaway close to Panama City