Centro is in San Luis Potosí.
Unlike the rest of the Altiplano, the residents in the capital city region mainly live in cities.
The mines spurred the early development of the city of San Luis Potosí. It played an important part in the war for Mexican independence along with other mining centers. In the War of Reform, the city was for a short time the capital of the country. The Mexican Revolution began with the escape of Francisco Madero from prison in San Luis Potosí.
The capital is one of the best in Mexico for colonial architecture. It is known for its strong artistic tradition. The Instituto Nacional de Bellas Artes and the Instituto de Cultura de San Luis Potosí have sponsored the Premio Nacional de Cuento (National Story Prize) over the last 20 years to encourage good writers. An active music community has led to the recent founding of the Orquesta Sinfónica de San Luis Potosí.
- Central Plateau (Altiplano) – This region has a rich mining tradition in gold, silver and zinc. The railroad later brought development and a strong participation in the national politics of Mexico.
- Río Verde Valley (Region Medio) – A rich agricultural region of mostly rural character.
- Huasteca Potosina – Coastal plains and the eastern reach of the Sierra Madre with a distinct culture greatly influenced by the Huastec Indians.