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It is the southern terminus of former railroad Estrada de Ferro Madeira-Mamoré.
Buses go to Porto Velho, five-seven hours away (333 km. to the north).
The town is small enough to reach most places by foot.
- Guaporé Nature Reserve
- The 18th century fort of Príncipe da Beira is three days by boat from Guajará-Mirim. It can also be reached by road. Take BR-364 to AM-429, which goes to the town of Costa Marques.