- 1 Owensboro–Daviess County Regional Airport (OWB IATA). Allegiant Air from Orlando/Sanford, Cape Air from St. Louis
- The River Park Center. The arts and cultural center for the Owensboro-Daviess County Region. Featuring many well renown and accredited Plays and Operas.
- 1 International Bluegrass Museum.
Owensboro is known as 'The City of Festivals.' Serving host to many local and international festivals and fairs. Owensboro is also considered 'The Number One Sports Town' in Kentucky.
- The International Bar-B-Q Festival
- The Apple Festival
Owensboro is known for two dishes, barbecue and burgoo. If you haven't heard of the second: it's a traditional stew originally made with squirrel or venison, but now made with mutton, chicken, beef and vegetables.
- Moonlite Bar-b-q Inn, 2840 W Parrish Av, ☏ .
- Ramada Inn, 3136 West 2nd Street, ☏ . HWY 60 West.
Most telephone numbers in Owensboro consist of +1 270 plus a seven-digit number, but the western third of Kentucky is now served by an overlay complex of two area codes, with +1 364 being the second. A local or in-state telephone call now requires all 10 digits of the local number be dialed (omitting just the leading +1 from a local landline call). The same is true on the Indiana side of the river, which has its own overlay complex of 812 and 930.
Signage on many established businesses may still display the original seven-digit numbers; dial 270 before these if no area code is indicated (or 812 if in Indiana).
Henderson, to the west, is the home of Ellis Park, a thoroughbred horse track that races in the summer months.
To the south are two towns that gave birth to musicians. Rosine is the birthplace of Bill Monroe, the father of Bluegrass music. Central City is the birthplace of Don Everly, the older of the two Everly Brothers, famous for countless hits including "Bye, Bye Love" and "Wake Up Little Susie". (The other brother, Phil, was born in Chicago.)
|Routes through Owensboro|
|END ←||N S||→ Hartford → Bowling Green|
|Evansville via ← Henderson ←||W E||→ Fort Knox → Louisville|
|Lafayette ← Jasper ←||N S||→ Hartford → Bowling Green|
|END ←||N S||→ Jct → Lewisburg → Nashville|