San Francisco - take Interstate 5 North to Interstate 580 West and follow signs for San Francisco. Allow lots of time during peak hours.
San Jose- 5 North to 580 West to 680 South, about 1 h 30 min to 2 h 30 min. For a scenic, but longer alternative route, you could take Del Puerto Canyon Road to Mt Hamilton to San Jose, which would take 1 h longer.
Los Angeles - 5 South, about 4 hours 45 minutes to 6 hours. Caution: Between Patterson and The Grapevine, there is not a lot of services, so bring lots of water and don't leave pets and children in cars during the summer.
Fresno - 5 South to 152 East to 99 South, about 2 h away.