Northern Interior is a region of Uruguay and includes the departments of Artigas, Paysandu, Rivera, Salto and Tacuarembo.
- Bella Unión
- Minas de Corrales – see the remains of 19th-century mines
- Salto - citrus growing town just across the Rio Uruguay from Concordia in Argentina.
- Tacuarembó - an important centre of the Gaucho culture
- Valle del Lunarejo (Rivera) - a national park
- Montes del Queguay (Paysandu) - a reserve in process of becoming a national park
- Palmeras (Paysandu) - Paysandu in particular is abundant with local palms (Yatay Palm). On the Argentinian side of the border they are protected in the national park El Palmar.
- Guichon (Paysandu) - Where the last Charruas were subdued in the 19th century. Now a popular bath resort. There is a monument commemorating the Charrua victims at Salsipuedes. The remains of the Tapera de Melchora Cuenca, Artigas' (the Uruguayan commander) indigenous wife.
This is gaucho (South American cowboy) territory. Don't be surprised to see men in distinctive, old-fashioned clothes riding horses down city streets or beside the highway. Outside of the downtown areas of major cities, you'll see cows and horses grazing almost anywhere you go.