Rio de la Plata is a region in Uruguay and includes the departments of Greater Montevideo, Canelones, Colonia, Rio Negro, San Jose and Soriano.
- Montevideo - capital city of Uruguay
- Colonia (Colonia del Sacramento) - old colonial city and a UNESCO World Heritage Site.
- Mercedes (Soriano) -Pinacoteca Gimenez and Casa Puerta are art museums worth a visit in this colonial town.
- Fray Bentos (Rio Negro) - A city which used to feature one the world's most prominent meat factories. Now it houses a museum.
- San Jose
- Carmelo, Nueva Helvecia, Colonia Valdense - pastoral colonial towns near Colonia
- Conchillas – a small town near Colonia, with English architecture left over from its original founders
- Nueva Palmira
- Villa Soriano- 18th Century colonial architecture and the first European settlement in Uruguay. A famous cemetery.
- Rosario - a small town featuring many outdoor murals.
- Estero de Farrapos - a national park and a protected Ramasar wetland of international significance. It is considered the best spot in Uruguay to observe wild animals. Gateway to the park is the town of Nuevo Berlin.
This region is home to both of Uruguay's UNESCO World Heritage sites: the old city in Colonia and the meat-packing complex in Fray Bentos. Beyond that, there are lovely little towns scattered through the region's farmland, as well as beaches on the shores of the enormous river.
Certain neighborhoods in Montevideo and some of its suburbs are best avoided, but other than that, the region is safe.