Wytheville is located at the intersection of two interstate highways. I-77 and I-81 provide access from the neighboring states of North Carolina, Tennessee, and West Virginia. I-81 also connects Wytheville to the larger metro areas of Northern Virginia.
- 1 Greyhound, 926 Max Meadows Rd.
- 1 Comfort Inn, 2594 East Lee Hwy, ☏ .
- 2 Comfort Inn, 315 Holston Rd, ☏ .
- 3 Comfort Suites, 695 Peppers Ferry Rd, ☏ .
- 4 Econo Lodge, 280 Lithia Rd, ☏ .
- 5 Quality Inn & Suites, 2015 E Main St, ☏ .
- 6 Ramada Wytheville, 955 Peppers Ferry Rd., ☏ .
- 7 Sleep Inn, 135 Nye Circle, ☏ .
- 8 Super 8, 130 Nye Circle (I-77 exit 41), ☏ . Low cost no frills hotel offering a continental breakfast and free wifi.
|Routes through Wytheville|
|Charleston ← Bluefield ←||N S||→ Jct E → Union Grove → Charlotte|
|Roanoke ← Radford ←||N S||→ Bristol → Kingsport|
|Huntington ← Bluefield ←||NW SE||→ Mount Airy → Winston-Salem|