Fullington Trailways, an intercity bus provider, has its main hub in DuBois. Routes are available to and from Erie, Buffalo, Pittsburgh, and State College, as well as several other smaller cities throughout western Pennsylvania and New York's Southern Tier.
Dubois Regional Airport has nonstop service on United to Cleveland and Franklin.
|Routes through DuBois|
|Youngstown ← Clarion ←||W E||→ Clearfield → State College|
|END ←||N S||→ Punxsutawney → New Stanton|
|Salamanca ← Ridgway ←||N S||→ Johnstown → Somerset|
|Meadville ← Clarion ←||W E||→ Clearfield → State College|
|Salamanca ← Ridgway ←||N S||→ Punxsutawney → Morgantown|