Karoo Heartland is in the Eastern Cape of South Africa.
Cities
- Aberdeen
- Cradock
- Graaff-Reinet
- Middelburg
- Nieu-Bethesda, a remote artistic community.
- Somerset East
- Steytlerville
- Tarkastad
Other destinations
- Camdeboo National Park (previously the Karoo Nature Reserve)
- Valley of Desolation near Graaff-Reinet (a spectacular part of the national park)
- Mountain Zebra National Park