- 1 Regina - the capital of Saskatchewan
- 2 Caronport
- 3 Estevan - South East
- 4 Fort Qu'Appelle
- 5 Lumsden - includes neighboring Craven and Regina Beach
- Maple Creek
- 6 Moose Jaw - South Central
- 7 Swift Current
- 8 Weyburn - South East
- 1 Cypress Hills Interprovincial Park
- 2 Grasslands National Park
- 3 Lake Diefenbaker and surrounding regions
- 4 Moose Mountain Provincial Park
The southwest part of the region has some unique spots that are not typical of a prairie landscape. Straddling the border between Saskatchewan and Alberta, the Cypress Hills Inter-Provincial Park rises 600 m above the surrounding prairie and is home to a sub-alpine lodgepole pine forest. South of Leader "The Great Sand Hills Ecological Reserve" is approximately 1,900 km² of ever-changing sand dunes. With 800 km of shoreline Lake Diefenbaker on the South Saskatchewan river is southern Saskatchewan's "Great Lake". The Big Muddy and Killdeer Badlands are very rugged hills and valleys carved by meltwater at the end of the last ice age.
Southwest Saskatchewan is the heart of Canada's own "Old Wild West".
The major industries are ranching and farming although the petroleum industry is growing in the western part of the region.
The Trans-Canada Highway (Highway #1) runs across the region (including Regina and Moose Jaw), connecting Southern Saskatchewan to Alberta and Manitoba. Saskatchewan Highway 11 connects Regina to Saskatoon in Central Saskatchewan.
If travelling by plane, most people will arrive at Regina International Airport in Regina, which is served by Air Canada and WestJet from various cities across Canada, plus Phoenix, Las Vegas and Orlando.