- The A1, a major north-south intercity road, bypasses the town to the west, the road is dual carriageway and is grade separated until St Neots to the south, and as far away as Newcastle in the North. London is only 100 miles to the south. To the north is Newark, Doncaster, which take up to half an hour to reach with clear traffic. The road goes as far as Edinburgh in Scotland, passing by Newcastle upon Tyne, Durham, and Darlington.
- The A52 is a major east-west route going through the centre of the town, Nottingham, Derby and Stoke-on-Trent are reached westwards; while Boston, and Skegness are reached going eastwards.
- The A607 is a secondary route linking Lincolnshire's county town of Lincoln in the north, with Leicester to the south, going through Melton Mowbray as it does so.
Grantham is on the main north-south line between London and Edinburgh. Various companies operate services. From London King's Cross, Hull Trains are both the cheapest and fastest at the moment with a 1 hour non-stop train for GBP25 one way.
A second line also runs east-west and connects Grantham to Nottingham.
- St Wulfram's Church has an imposing spire, the sixth highest in England, and dominates the centre of town.
- Belvoir Castle (8 miles west of Grantham, just over the border in Leicestershire), ☎ , e-mail: email@example.com.
- The King's School is the school that Isaac Newton attended. The part he was taught in is now the library, and while it is not open to the public it can be seen from the St Wulfram's side of the school site.
- Birthplace of Margaret Thatcher