Western Illinois is a region of Illinois generally bounded by the Mississippi River to the west, I-80 to the north and I-39/I-55 to the east. It has two major anchors: Peoria and the Illinois side of the Quad Cities. Being culturally similar to Central Illinois, they are sometimes presented together as the same region.
- Forgottonia is a region in the greater Western Illinois region of Illinois. The name refers to the tongue-in-cheek independence movement the area held in the 1970's following a series of setbacks which damaged the long-term economic development prospects of the region including the defeat of interstate and passenger rail projects and the moving of Carthage College from Carthage, IL to Kenosha, WI. The region is also uniquely divided from the rest of the state as the majority lies between the Mississippi and Illinois Rivers and can only be reached by limited bridge access. Though definitions may vary, the region traditionally includes the entirety of 14 counties including Adams, Brown, Calhoun, Fulton, Hancock, Henderson, Knox, McDonough, Morgan, Pike, Schuyler, Scott and Warren. By and large, the entire area is rural but has some attractions worth seeing.
- The Illinois Quad Cities—4-headed metro region in western Illinois and Eastern Iowa containing Rock Island and Moline. Davenport and Bettendorf are on the Iowa side of the Mississippi.
- Greater Peoria: The region immediately surrounding Peoria.
- Arenzville - home of the Arenzville Burgoo
- Quincy - The southern anchor city of the region, Quincy is a port city on the Mississippi River.
- Nauvoo - original home of LDS founder Joseph Smith
- Peoria - the largest city in Western Illinois, Peoria is home to Bradley University, an interesting riverfront with minor-league baseball and is also home to headquarters of Caterpillar and other large companies.
- East Peoria
- Moline (home of Western Illinois University - Quad Cities Campus) and Rock Island - two of the Quad Cities
- Jacksonville- home of Illinois College, the first college in the state
- Washington - unique town with big city conveniences and small town charm.
- Galesburg - the northern anchor city of the region, home of Knox College and poet Carl Sandburg.
- Macomb - home to Western Illinois University
- Rock Island
The best way to travel throughout the region is by car. I-74 is the primary thoroughfare and connects anchor cities Peoria and Rock Island. It also provides service to the Illinois Twin Cities (Bloomington and Normal) and the Urbana and Champaign area. US 24 serves as a secondary thoroughfare and connects Peoria to Quincy another anchor city located on the Mississippi. Interstate 72 also provides some service to the southern portions of the region.