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Southeast Region of Missouri.
- 1 Alton
- 2 Cape Girardeau
- 3 Eminence
- 4 Charleston — Hometown of former Governor Warren E. Hearnes. Visit in the springtime.
- 5 New Madrid
- 6 Poplar Bluff
- 7 Sikeston
- 8 Ste. Genevieve
- 9 West Plains
- 10 Van Buren
- A total solar eclipse on Monday 8 April 2024 crosses this area from about 1:55PM local time. The track of totality is northeast from Mexico, Texas and Arkansas across the southeast corner of Missouri, then on into Illinois and Indiana.
- Big Springs Park — on the outskirts of Van Buren, it is one of North America's largest freshwater springs.
- Historic downtowns of Charleston and Cape Girardeau.
The Black, Current, North Fork of the White, and their tributaries are a major draw for recreational canoeing and kayaking. There are many outfitters in this region who can help you plan a trip.
- 1 Elephant Rocks State Park, 118 E Maple St Pilot Knob, MO 63663 (on Highway 21 just north of Ironton), ☏ . April–October, 8AM-8PM; November–March: 8AM-5PM. Climb around on gigantic reddish granite boulders, or enjoy a picnic and the lovely walking trails (with braile signage) around the park. The monolithic rocks overlook an old quarry and abandoned firehouse. The park is open year-round, but can get crowded on warm weekends. Camping is not allowed. free.
- 2 Johnson's Shut-Ins State Park, 148 Taum Sauk Trail Middlebrook, MO 63656 (SOUTH on State Highway N off of Highway 21, north of Ironton), ☏ . 8AM-6PM Spring and Fall; 8AM-7PM Summer; 8AM-4PM Winter. After being closed in 2009 by a disastrous flood, Johnson Shut-Ins is again open, and has a new boardwalk that overlooks the shut-ins. The shut-ins refer to a natural formation where the East Fork Black River has run over igneous rock and eroded a maze-like series of channels, rivulets, and cascades. It is a sort of natural water park, and many people come to swim and play here during the warm months. Hiking, Camping, and a visitor's center are available in the park.