Interstate 10 (I-10) is a United States interstate highway that starts at the Pacific Coast in Santa Monica, California and runs 2,460 mi (3,960 km) east through the states of California, Arizona, New Mexico, Texas, Louisiana, Mississippi, Alabama and Florida to the Atlantic Coast in Jacksonville, Florida. It serves as an important southern tier transcontinental highway across the Southwest and southeastern U.S. connecting the major cities of Los Angeles, Phoenix, Tucson, Las Cruces, El Paso, San Antonio, Houston, New Orleans, Gulfport/Biloxi; Mobile, Pensacola and Jacksonville; and the three state capitals of Arizona (Phoenix), Florida (Tallahassee), and Louisiana (Baton Rouge). It is the third longest transcontinental interstate highway behind Interstate 90 (Seattle to Boston on the northern tier) and Interstate 80 (San Francisco to New York City on the middle tier); and the fourth longest east to west interstate after Interstate 40 (Barstow, California to Wilmington, North Carolina).

Understand

Interstates 8 and 10 carry much of the Old Spanish Auto Trail (OST) between San Diego, California and Jacksonville, Florida which is also overlapped by the Dixie Overland Highway between the I-20 junction in West Texas and San Diego. The historic highway itself spanned from St Augustine, Florida to San Diego, California via San Antonio, Texas and is often referred to as the "(old) US Route 66 of the South." After 1926, when the US Highway numbering system was implemented, the OST became U.S. Highway 90 east of San Antonio and US Hwy 80 in West Texas towards San Diego. Between those points, portions of U.S. Highway 87, Texas State Highway (SH) 27, and a pre-1991 alignment of U.S. Highway 290 (west of Fredricksburg) replaced the OST. A third option (OST 3) served as an alternate route to the OST on the present US Hwy 90 from San Antonio, westward towards Del Rio via Uvalde. From Del Rio it (US Hwy 90/OST 3) winds northwesterly towards Van Horn through Langtry, Dryden, Alpine and Marfa and ends at the old US Hwy 80 (OST 1), north of its intersection with I-10 in Van Horn, Texas. A second option (OST 2) branches from San Antonio and follows the present day I-37 towards Corpus Cristi and then on US Hwy 77/I-69E south to Brownsville where it ends. The original Old Spanish Auto Trail begins at the Huguenot Cemetery in Saint Augustine and ends at Horton Plaza Park in San Diego. Intestate 10 supersedes US Hwy 90 east of San Antonio and replaces US Hwy 80, 60 and other US and state highways between San Antonio and Los Angeles. Interstate 8 replaces the remaining section of the Old Spanish Trail and the Dixie Overland Highway (US Hwy 80) from Gila Bend, Arizona to San Diego. U.S. Highway 1 continues the Old Spanish Trail from Jacksonville to its eastern terminus in St Augistine.

Promoters of the Old Spanish Trail claimed that it followed the route used by "Spanish Conquistadors" 400 years earlier, but there was no continuous trail or road from Florida to California during Spanish times nor did it bear any relationship with earlier Spanish Cattle Trails that existed between Los Angeles, Barstow and Santa Fe, New Mexico during Spanish times.

The only toll section of I-10 is a 13 mi (21 km) stretch between I-610 Loop and TX-Hwy 6, west of Houston, known as the "Katy Managed Lanes". The Katy Managed Lanes consist of four inner lanes of 18 total lanes that are tolled, while the other outer lanes are toll-free. Elsewhere, most of I-10 is toll-free.

Prepare

See also: Driving in the United States

See also: Hot weather

In the southwestern deserts between San Antonio, El Paso, Tucson, Phoenix and Indio/Palm Springs, or going off of the I-10 corridor, there are few, if any, services as they are further apart! In some places it can be over 100 mi (160 km) which can be dangerous with summer temperatures over 110 °F (43 °C). Carry fresh drinking water during every cross-desert travel. Make sure your vehicle is in good, non-overheating condition, with a cool A/C, and also make sure the vehicle has a full tank of gas before leaving a city, town or from last night's accommodations. Charging stations for electric vehicles are further apart.

Get in

Interstate 10 begins/ends at its junction with Pacific Hwy (CA-1) on the Pacific Coast in Santa Monica. Going west the freeway simply goes through a tunnel and curves north as Pacific Highway (CA-1). In the east coast it begins/ends at its junction with Interstate 95 in Jacksonville where I-10 splits up towards (or merge from) different directions. To continue further east towards the Atlantic Coast, one can travel another 20 mi (32 km) on US-90 (Beach Blvd) from I-95 to its intersection with FL-A1A in Jacksonville Beach. I-10 intersects other major US interstate highways (Interstates 5, 8, 15, 17, 25, 20, 35, 45, 49, 55, 59, 65, 75 and 95); various three digit interstates (serving as local auxiliary highways), state highways, U.S highways and local roads in the eight states where travelers can enter and leave I-10.

By plane

See also: Air travel in the United States

The Interstate 10 corridor can be accessed by plane through Los Angeles/LAX, Ontario, CA; Phoenix, Tucson, El Paso, San Antonio, New Orleans, Gulfport-Biloxi, Pensacola and Tallahassee with airports next to or near the freeway. In other cities, such as Jacksonsville, Austin, Houston and Long Beach the airport is further away (10-40 mi/16-64 km) from the I-10 corridor on another highway.

Go

By train

See also: Rail travel in the United States

Amtrak Sunset Limited (interactive map)

Amtrak operates trains "more or less" along the Interstate 10 corridor serving the major cities in Southern California, the Southwest, Texas and the Southeastern part of the country. Some segments are further away from I-10 such as the segment between Palm Springs and Maricopa, Arizona and from El Paso to San Antonio, Texas while other parts of the route are practically next to the freeway such as the section between Tucson, Arizona and El Paso. The following trains operate along the I-10 corridor:

• The Sunset Limited runs three times a week from New Orleans to Los Angeles via Houston, San Antonio, El Paso, Tucson, Maricopa (nearest stop to Phoenix), Yuma, Palm Springs and points in between. Additionally, Amtrak's Texas Eagle service between San Antonio and Chicago incorporates the Sunset Limited to provide a direct connection to Los Angeles with the same stops as the Sunset Limited from San Antonio. There are Thruway bus connections between the Sunset Limited in Houston and the Texas Eagle in Longview, Texas; and between Maricopa and Phoenix.

• The MetroLink is an extensive regional train network in Southern California with rail lines radiating out from Los Angeles Union Station to surrounding suburbs and counties, stretching as far as Perris, Lancaster, Oceanside, San Bernardino, Riverside and Oxnard. The San Bernardino and the Riverside Lines closely parallel the 10 through east L.A. and the Inland Empire to San Bernardino and Riverside respectively. There are connections to local and regional public transportation (Foothills Transit, LA Metro, Omnitrans, RTA, etc) at each station and cross platfrom transfers with Amtrak's Texas Eagle and Sunset Limited through Los Angeles Union Station, Pomona and Ontario from MetroLink's Riverside Line.

By bus

See also: Long-distance bus travel in the United States

There are several bus companies operating buses along the I-10/US 90 corridor with Greyhound serving the entire length while other companies operate buses along certain sections of I-10 to make the journey possible without a car. Bus company listings marked with the Mexican flag are those that offer onward connections further south of the border to as far as Mexico City. See By bus under Get in in a particular city article for a list of bus companies and their bus station/stop locations:

• Greyhound Lines, toll-free: +1-800-231-2222. Greyhound does not travel the entire I-10 corridor but in the following segments:

• Los Angeles - Phoenix - El Paso
• El Paso - San Antonio - Katy - Houston once daily. Most of their buses are routed through Dallas (via I-20) where passengers transfer buses to San Antonio (via Waco, Austin on I-35), to Houston (via I-45), or Atlanta (on I-20) to get towards Jacksonville or Orlando.
• Houston - Baton Rouge - New Orleans - Mobile. Some variations of this route continue east towards Orlando (via Tallahassee) from Mobile but would bypass New Orleans via I-12 between Baton Rouge and Biloxi. Check schedules on website regarding departures from New Orleans.
• Mobile - Tallahassee - Lake City - Orlando.
• Tallahassee - Lake City, FL - Jacksonville

Travelers booking tickets between Houston and Jacksonville are typically routed through Atlanta via Mobile or New Orleans. There are additional stops along the way between the cities listed above. Check their schedules on their website. (updated Jun 2023)

• El Paso Los Angeles Limousine Express, (El Paso bus station) 720 S Oregon St, El Paso TX (S Oregon and E 6th St in downtown El Paso), ☏ +1 213 623-2323, +1 915 532-4061. Travels along I-10 between Los Angeles, Indio, Phoenix, Las Cruces and El Paso with additional stops in E. Los Angeles, El Monte and San Bernardino on Interstate 10. Their Los Limousines buses continue south of the border towards Chihuahua City via Ciudad Juarez. (updated Apr 2016)
• Flixbus (operated by various bus companies), ☏ +1 855 626-8585. Operates buses (on contract with different bus companies) from Los Angeles to El Paso via Phoenix and points in between. They also have another segment between Houston and New Orleans via Beumont/Vidor and Baton Rouge. (updated Jun 2018)
• Megabus. Megabus connects San Antonio to Houston on I-10. Other routes are from Dallas to San Antonio and to Houston, on two separate routes. There's also another Megabus route in Jacksonville but it only goes south towards Orlando via Daytona Beach (via I-95/4) and north to Atlanta. 
• Omnibus Express, ☏ +1 602-272-3030. They offer bus service between Los Angeles, Phoenix, Tucson and Nogales in U.S. on I-10 & 19, and from Nogales to Cualican along Fed Hwy 15 through multiple cities in Sonora and Sinaloa. (updated Oct 2017)
• Tornado Bus Co. & El Expreso, ☏ +1-915-351-9002, toll-free: +1-888-358-6762. They operate a once daily bus from El PAso to San Antonio on I-10 while most of their buses are routed through Dallas where passengers change buses to reach San Antonio or Houston. They have more buses traveling between San Antonio and Houston, and from Houston towards Homestead or Plant City, Florida (on two separate routes). Tornado buses serve Beaumont, Lake Charles, Baton Rouge, Lafayette, Hammond, and Biloxi etc on the I-10/12 corridor between Houston and Lake City. They also offer onward connections to Mexico from San Antonio and Houston towards Laredo/Nuevo Laredo; McAllen/Reynosa;and Brownsville/Matamoros. Check schedules or call. 
• Tufesa, (Los Angeles bus station) 611 Maple Ave (Along Maple Ave between 6th & 7th), ☏ +1 213 489-8079. Connects Los Angeles to Hermosillo via Phoenix, Tucson and Nogales. Travels on I-10, 19 and Mex Hwy 15/15D. In Los Angeles they have another station at 5201 E Olympic Blvd in East L.A. Prices vary depending on your destination. (updated Nov 2022)
• Turimex (subsidiary of Grupo Senda), ☏ +1 800 980-1300. Operates buses from San Antonio to Houston, Baton Rouge, Biloxi and Mobile. (updated Jun 2018)

There are additional express and local buses operating as local public transportation along I-10 at varying distances in different places. These options are generally cheaper and more frequent than Greyhound or other intercity companies for the same distances but they are slower with more frequent stops and transfers than with Greyhound. They are generally most available almost contiguously on the first/last 142 mi (229 km) in Southern California, from Santa Monica to Indio. Local public transportation is infrequent or unavailable along most other sections of I-10 especially in remote rural areas. The following are most notable:

• Big Blue Bus Rapid 10. Big Blue Bus is operated by the City of Santa Monica to provide local public transportation in and around Santa Monica, California. The Rapid 10 bus operates as an express bus along the first/last 20 mi (32 km) section of I-10 between Santa Monica and the downtown Union Station via downtown Los Angeles. 
• Foothills Transit Silver Streak Line. Foothills Transit provides local public transportation in/between the various cities of the San Gabriel and Pomona Valleys, east of downtown Los Angeles and in Pasadena. The Silver streak operates fequent express buses from downtown L.A. to Cal State LA, El Monte, Westfield West Covina, Pomona Transit Center (Riverside Metrolink & Amtrak Sunset Limited) and Montclair Transit Center (San Bernardino Metrolink) on a 24/7 schedule. The #699 bus runs a more direct route from downtown L.A. to Montclair Transit Center with fewer stops in between. Passengers transfer to the San Bernardino Metrolink train to get to the Sun Line Transit #10 bus in San Bernardino. 
• Sun Line Commuter Link #10. Sun Line Transit operates local public transportation in the Coachella Valley between Palm Springs, Palm Desert and Indio, California. The #10 Commuter travels along a 75 mi (121 km) stretch of I-10 from San Bernardino to Indio via CSUSB main campus, Beaumont and CSUSB in Palm Desert 
• New Mexico Park & Ride Gold Line, ☏ +1 866-551-7743. Bus operated by the New Mexico Dept of Transportation throughout New Mexico state on multiple routes. In southern New Mexico the 'Gold Line' bus only connects Las Cruces to Anthony, Texas; and El Paso along I-10. 
• Transporte Ruta Binacional, (Downtown El Paso bus station) 410 S Santa Fe St (SE corner of S Santa Fe & Paisano), ☏ +52 656-170-84-93 (MX), +1 915-235-8268 (US). Daily 7AM-9PM, every hour. Local public transportation operated by a Mexican company connecting Ciudad Juarez to El Paso (travels on I-10 from downtown, El Paso Airport to El Cielo Mall). In Ciudad Juarez, they serve the Juarez Bus Station, Juarez Airport, the US Consulate and downtown Cd Juarez. $2 to downtown Ciudad Juarez to $20 to the US Consulate south of Ciudad Juarez. (updated Jul 2019)
• Greyhound Quicklink. Quicklink is a subsidiary brand of Greyhound Lines to serve as a frequent local/regional commuter bus between Baton Rouge, Gonzales, LaPlace, Houma and New Orleans on I-10 & US Hwy 90. 
• Jacksonville Transit Authority (JTA). JTA operates as local public transportation in/around Jacksonville. They travel the first and last 23 mi (37 km) between the downtown Jacksonville transit center (JRTC) (across the street from the Greyhound station) and Jacksonville Beach at 3rd St S (FL-A1A) & 4th Ave S on the Atlantic Coast with the following:. 

• 10 Atlantic Blvd travels along the Arlington Express Way (FL-115) and Atlantic Blvd (FL-10) to JAX Beach from the downtown Rosa Parks Station.
• 109 Red Line Flyer travels along the Arlington Express Way Service Rd (FL-115), Southside Blvd, and Beach Blvd (US-90)(with limited stops) from Rosa Parks Station to JAX Beach on 3rd St S & 4th Ave S.

There are no JTA bus services west on I-10 from Jacksonville to the western suburbs.

See or add to By bus under Get around or Get in, in a city or town article for an additional list of local public transportation companies serving the city or town.

Drive

Note: State highways are referenced by their postal abbreviations, e.g., CA-60 means California State Highway 60, MS-15 means Mississippi State Highway 15, etc. Attractions and cities are listed in bold are linked to their respective Wikivoyage articles for further reading and discussion. If no such article exists on Wikivoyage it is linked to its Wikipedia article. Please feel free to plunge forward to edit this or another article or create a new Wikivoyage article that does not yet exist. Click here for a map of the Old Spanish (Auto) Trail.

Mile markers are statewide mileposts, starting with "0" at the western border of each state which increases as you go east and then starts over at "0" when crossing the state line into the next state. So going west the numbers on the mileposts will decrease and then start over at the highest number when crossing a state line. The exit numbers correspond with the mileposts so some numbers may be skipped if the exits are further apart from one to the next. Other exits that are one next to the other or "2 in 1" may have the same exit number followed by an "A", "B" or even a "C" such as "Exit #100A" to get on A St, "Exit #100B" to get on B St and so forth.

California

The maximum speed limit is 70 mph (112 km/h) for cars on rural stretches and 65 mph (90 km/h) in urban areas or lower if posted otherwise. Speed limit for large trucks is 55 mph (88 km/h) in both rural and urban areas.

The segment of I-10 in California runs east from Santa Monica through Los Angeles, San Bernardino, and Palm Springs before crossing the desert and into the state of Arizona. In the Greater Los Angeles area, it is known as the Santa Monica Freeway and the San Bernardino Freeway, linked by a short concurrency on I-5 (Golden State Freeway) at the East Los Angeles Interchange. I-10 also has parts designated as either the Rosa Parks Freeway, the Redlands Freeway, or the Christopher Columbus Transcontinental Highway. I-10 is also known colloquially as "the 10" to Southern California residents

I-10 replaces the section of US Hwy 60 & 70 (paired) between Brenda, Arizona to Beaumont, California where US Hwy 60 and 70 splits. From Beaumont, US Hwy 60 followed the Moreno Valley Freeway (CA 60 & part of I-215), through the Moreno Valley, Riverside, and to CA-71 in Pomona where it rejoined the San Bernardino Freeway (present I-10). US Hwy 60, 70 and 99 were multiplexed on the present I-10 from Indio, through Beaumont (where US Hwy 60 left), to its intersection with CA-71 where US Hwy 60 rejoined the San Bernardino Freeway into downtown Los Angeles as US Hwy 60, 70 & 99. US Hwy 99 ran concurrent along the present I-10 from Indio to its intersection with US Hwy 101 in downtown Los Angeles where it went north along the present Interstate 5 through the San Fernando Valley. Going south US Hwy 99 followed the present CA-Hwy 86 from Indio to Brawley along the western shores of the Salton Sea. From Brawley, US Hwy 99 followed CA-111 to the Mexican border in Calexico where it ended/began. After 1964 the remaining sections of US Hwy 60 on the Moreno Valley Freeway and the Pomona Freeway were renumbered to CA-Hwy 60 while the remainder (old US Hwy 70, 99) became I-10. US Hwy 99 was decommissioned in favor of I-5 and CA-99. Eventually the section of present day CA-60 (Pomona Fwy) continues from CA-71, through Pomona, Diamond Bar and City of Industry/Hacienda Heights, to I-5 in downtown Los Angeles after the completion of the remaining section(s) that were under construction.

• Business Loop (BL)-10 serves as an auxiliary surface street branching from the interstate through Blythe as Hobson Way and along the eastern edge of Indio on 'Old Hwy 86' to the intersection of CA-86 and 111 SE of town. They replace a section of the old US highway (US Hwy 60 & 99) that once went through town as a local street.

I-8 replaces the Old Spanish Auto Trail (US Hwy 80) from Gila Bend, Arizona to its western terminus in San Diego. There are sections of the old US Hwy 80 remaining as a two lane road alongside I-8 through Arizona and California continuously. Parts of the old US 80 goes through Yuma and Calexico as BL-8. Other sections of the OST (US 80) in California have been abandoned as a road for vehicular use and serve as hiking trails. I-8 and old US 80 go through Yuma and El Centro/Calexico to get to San Diego.

• 1 Santa Monica - A popular seaside community famous for its beach and amusement park pier, with a bustling shopping promenade.

Eastbound entrance into the McClure Tunnel

• East to Los Angeles, Coastal Route (Rte) (Mile 0.0). CA-1 curves eastwards through the McClure Tunnel where the road becomes I-10 past the Lincoln Blvd exit. 
• Lincoln Blvd (EB)/4th & 5th St (WB) (Exit 1A). Going west Interstate 10 officially ends at the 4th St overpass where a sign reads, "FREEWAY ENDS." The freeway continues the rest of the way into the tunnel where it curves north and becomes Pacific Highway (CA-1). CA-Hwy 1 continues south from its junction with I-10 towards LAX, through Santa Monica, on Lincoln Blvd. 
• Lincoln Blvd (WB)/20th St (EB) (Exit 1B). 
• Colverfield Blvd (Exit 1C). Westbound access only. 
• Centinela Blvd/Pico Blvd (Exit 2 (EB Side)/2A (WB side)). 
• Bundy Dr North (via 2C); Bundy Dr South (via 2B) (Exit 2B/2C). Westbound access 

• 2 Culver City - Best known for film and TV production, including the old MGM studios, which is now part of Sony Pictures. Also noted for its excellent dining scene, local shops, and a couple of intriguing museums, including the quirky Museum of Jurassic Technology.

• North to Sacramento; South to LAX, Long Beach (Exit 3). I-10 is accessed from Exit 53 of I-405. 

• 1 Los Angeles International Airport (LAX ^IATA). Go south on I-405 from I-10 to "Century Blvd/LAX Airport" (at Exit #46 from SB side or Exit #48 from NB side of 405). Likewise travelers can get off at Lincoln Blvd (CA-1) in Santa Monica and go south on Lincoln Blvd towards LAX at Century Blvd. Each rental car company have their own separate locations surrounding LAX for rental car returns. 

• National Blvd/Overland Ave (Exit 4). signed only as "Overland Ave" from westbound lanes 
• National Blvd (Exit 5). westbound access only 
• Robertson Blvd Culver City (Exit 6). 
• La Cienga Blvd (Exit 7A). signed and access to " La Cienga Blvd/Venice Blvd" from westbound lanes. 
• Washington Blvd / Fairfax Ave (Exit 7B). 

From Culver City I-10 passes through the Westside where the rest of the world thinks of when they think"California". Beautiful beaches, fancy homes, movie stars: it's all there. I-10 also divides the Westide from South Central L.A. which is notorious for being a high crime area known and for being the epicenter of the race riots of 1967 and 1992. Surprisingly it is the location for University of Southern California, the museums and stadiums of Exposition Park, the famous Watts Towers, and significant centers of African-American culture.

• Western Ave (Exit 11). 

• 3 Los Angeles
  • . Interstate 5 north to Sacramento and south to San Diego. (updated Jun 2023)

The San Gabriel Valley encompasses the suburban valley communities (cities) east of Downtown Los Angeles, as well as the forested San Gabriel Mountains to the north of the valley.

The Inland Empire of Southern California is a semi-arid region, east of Los Angeles, made up of scores of cities and towns. The boundaries are often a subject of debate, however, it is generally agreed that the western boundary is the San Bernardino County/Los Angeles County line and the eastern limits are the most urbanized areas of San Bernardino County and Riverside County.

• 4 Ontario and 5 Upland

• Mountain Ave (Exit 50). 
• Euclid Ave (Exit 51). Divides Ontario from Upland 
• 4th Ave (Exit 53). 
• Vineyard Ave (Exit 54). goes by the Ontario Convention Center 
• Archibald Ave/Ontario Airport (Exit 55/55B). Direct access to the airline terminals at Ontario International Airport from the freeway. Exit 55 from EB side and 55B from WB side. 

• 2 Ontario International Airport (ONT ^IATA). 
• Holt Ave (Exit 55A). WB Access only. EB access through Vineyard Ave at Exit 54. 

• Haven Ave (Exit 56, Rental Car Return). Go south on S Haven to the Rental Car Center for rental car return. "Rental Car Return" not signed from the freeway. 
• Millikan Ave (Exit 57). Go north N Millikan Ave to get to Ontario Mills Mall a major retail hub in the area. 
• North to Barstow, Las Vegas; South to San Diego (Exit 58). I-10 is accessed from Exit 109 of I-15. Travelers going towards North Carolina, from L.A., (via Grand Canyon, Northern Texas, Oklahoma, Tennessee) will find it more efficient to travel on I-40 from Barstow than to continue east on I-10 through Phoenix (I-17), Texas (I-20/30), Alabama (I-65) or Florida (I-75/95). It's also a popular and a quicker route (I-10/15) for L.A. locals going on weekend trips to Las Vegas and for travelers touring Route 66 to get from Southern California to Amarillo, Texas. 

• 6 Fontana
• 7 Rialto
• 8 Colton

• North to San Bernardino, Barstow; South to Riverside (Exit 72). I-10 is accessed from Exit 40 of I-215. Travelers coming from the east or the Inland Empire (nearer the I-10/15/215 junctions) and going north on I-5/CA-99 towards Sacramento via the San Joaquin Valley can get off I-10 at I--215 which merges into I-15 north of San Bernardino (or at I-15 at Exit 58 between Fontana and Ontario). Go north on the 15 to CA-58 at Exit 179 in Barstow and go west on CA-58 to CA-223. Continue west on CA-223, past the south of Bakersfiled, to I-5 at Exit 239 (Bear Mountain Rd) of I-5 or continue west on the 58 past the 223 turn-off into Bakersfield to get to CA-99. This route bypasses the Los Angeles area. 

• 9 San Bernardino
• 10 Loma Linda
• 11 Redlands

The western portions of Riverside County include the far outskirts of the Los Angeles Metropolitan Area, as well as more rural areas like Temecula, known for its wineries and hot air balloons. The majority of the county lies in the desert, with the most-visited portion being Palm Springs and its neighboring resort towns. Further east the county is essentially uninhabited, and includes the remote, rocky desert of Joshua Tree National Park, and the empty landscapes west of the Colorado River.

• 12 Beaumont
• 13 Banning
• 1 Joshua Tree National Park encompasses nearly 800,000 acres (320,000 hectares) of the Mojave and Colorado Deserts, conserving two separate desert ecosystems at different altitudes. It is named from the distinctive Joshua tree (Yucca brevifolia), a tall-growing plant that grows prevalently in the higher elevations of its boundaries which dot the 800,000 acre park.
• 14 Palm Springs is a resort city in the California desert. It became a destination during the 1950s and 1960s when Hollywood movie stars flocked there in droves. Nowadays, the area offers entertainment for all ages, although the most common demographics consists of retirees. Palm Springs offers a wealth of indoor and outdoor activities. Known for its hiking, mid-century modern architecture, stunning natural beauty and sparkling pools, Palm Springs has the perfect blend of outdoor activities and casual relaxation.
• 15 Palm Desert lies in the Coachella Valley at the base of the San Jacinto Mountains. The city is home to many golf courses, attractions, luxury hotels and shops, and spas that make the region a famous getaway for much of Southern California.
• 16 Indio
• 17 Blythe

• Airport Mesa Dr (Exit 232).  Blythe Airport is off the freeway to north. It serves as a general aviation airport
• Neighbours Blvd, Brawley (Exit 236).  Brawley is 89 mi (143 km) south, towards I-8, from here.
• Lovekin Blvd (Exit 239). 
• 7th St Blythe (Exit 240). 
• Intake Blvd, Needles (Exit 243).  Going south on US Hwy 95 it continues east on I-10 to Quartzsite. US Hwy 95 goes north from here, on Intake Blvd, to Needles (96 mi (154 km) north).
• 7th St Blythe (Exit 240). 
• E Hobson Way (Exit 242).  Westbound exit and entrance only.
• Riviera Dr (Exit 243).  Eastbound exit and entrance only. Riviera Dr curves under the freeway and go back towards the other direction, on the other side, as E Hobson Way.

• 3 Blythe Agricultural Inspection Station (Mile 243), 7116 I-10 (4 miles east of Blythe, west of the state line on the Colorado River), ☏ +1 760 920-3666. All westbound traffic must stop for agricultural inspection. They're looking for fruits, vegetables, firewood, hay, nursery stocks and anything invasive that may be in violation of state and federal quarantine laws. (updated Jul 2019)

Crosses the Colorado River to/from Arizona

Arizona

The maximum speed limit is 75 mph (120 km/h) for cars and trucks on rural stretches and 65 mph (104 km/h) in urban areas or lower if posted otherwise.

& In Arizona, I-10 was built on a different alignment that only replaces US Hwy 80 between Benson and Tucson and US Hwy 60 west of Brenda to provide for a more straightforward and efficient path through the state. Between Brenda and Tucson and between Benson and the New Mexico State line I-10 replaces a series of other state highways. Meanwhile US Hwy 80 followed a different route than the present I-10 which is replaced by the following state highways after being decommissioned:

• & The Old US Hwy 80 splits from the present I-10 as NM-80 in Road Forks (Exit 5) to go south towards the Mexican border in Douglas, Arizona, through Rodeo, New Mexico. It becomes AZ-80 after crossing the state line. From Douglas, AZ-80 goes back north towards Benson through Tombstone and Bisbee. The Old US Highway 80 joins the present I-10 (at Exit 306) from Benson to Tucson. I-10 between Road Forks and Benson replaces old NM-14 and AZ-86 (concurrent with US Hwy 80 between Benson and Tucson) for travelers who want to keep going without taking the detour to Douglas. AZ-86 (W Ajo Way) ends at it junction with I-19 in Tucson.
• From Tucson the Old US Hwy 80 continued north on the present day AZ-77 (N Oracle Ave) to Oracle Junction and then along AZ-79 through Florence to US Hwy 60 in Florence Junction. US Hwy 80 ran concurrent with US 60,70,89 (on the same road) through Apache Junction, Queen Creek, Mesa, Tempe and Phoenix to approximately 7th Ave & Van Buren where US Hwy 60,70,89 go towards Wickenburg on Grand Ave. US Hwy 80 continued west on W Van Buren to 17th Ave where it turned south and then continued west from S 17th Ave, on W Buckeye Rd, to Goodyear. From Goodyear is curved southwesterly on MC-85 along the southside of Buckeye towards the Gila River.
• The historic US Hwy 80 runs alongside the Gila River, parallel with AZ-85 (a more straight path) at opposite sides of the Gila River to Gila Bend where the US Hwy 80 continued west towards San Diego via Yuma alongside the present I-8 as a two lane road.
• Business Loop (BL)-10 or 8 are remnants of the old US or state highways that were replaced by I-10 or I-8 that branches from the interstate into and through San Simon, Bowie, Willcox, Benson, Phoenix, Tucson, Quartzsite, and Yuma as a local street. They replace a section of the old US highway (60 or 80) that once went through town as a local street.

Going west from Phoenix to Los Angeles US Hwy 60 & 70 (both were paired on the same road from Globe to Los Angeles) leave Phoenix in a northwestly direction towards Wickenburg through Glendale and Peoria on Grand Ave and then southwest towards the present I-10 (Exit 31), west of Brenda, from Wickenburg. They than continued west towards Los Angeles along the present day I-10. US Hwy 60 ends at the (westbound) on-ramp to I-10, west of Brenda (Mile 31) while US Hwy 70 truncates further east in Globe. Between the US Hwy 60 exit near Brenda and Phoenix is a new addition to provide a straight path into Phoenix rather than routing I-10 upon US Hwy 60 through Wickenburg, Peoria and Glendale into Phoenix.

Entering into Arizona from California

Western Arizona is a remote region consisting of deserts and mountains. It is west of Phoenix and Tucson, north of the border with Sonora, Mexico, and east of the Colorado River which separates Arizona from California.

• Ehrenberg is a census designated place (unincorporated) located on the Colorado River, which forms the border with Riverside County, California, near the city of Blythe. It is situated close to Interstate 10, at the southern end of the Parker Valley and next to the Palo Verde Valley

• Ehrenburg Parker (Exit 1). 
• Tom Wells Rd (Exit 5). 
• Dome Rock Rd (Exit 11). 

• 18 Quartzsite

• " Parker Yuma" from EB side, signed "Quartzsite" from WB side (Exit 17).  Exits off at Main Event St. Go north to Main St and take a right (east) on Main St to get into town. AZ-95 and US-95 goes north-south through town as Central Ave. US Hwy 95 goes south towards Yuma while AZ-95 goes north towards Parker. Going north on US Hwy 95 it follows I-10 west into Blythe. Likewise, travelers going towards Needles can go north on AZ-95 from Quartzside to Parker and go west on AZ-62/CA-62 to Vidal Junction at US Hwy 95, north of Blythe. Turn north on US-95 to Needles from Vidal Junction, California.
• " Parker Yuma" from WB side; signed "Quartzsite" from EB side (Exit 19).  Exits Off at Riggles Ave. Go north to Main St and take a left (west) on Main St to go into town.
• Gold Nugget Rd Rd (Exit 26). 
• East to Wickenbug, Prescott (Exit 31). Historically US Hwy 60 & 70 (both were paired on the same road from Globe) used to continue west towards Los Angeles on the present I-10. Now US Hwy 60 ends at the west bound on-ramp while US Hwy 70 ends further east in Globe. 

• 2 Cibola National Wildlife Refuge, ☏ +1 928-857-3253. Visitor Center: Nov-Mar: daily 8AM-4:30PM; Lands, roads and trails: daily from sunrise to sunset. Established to protect and recreate the marshes and backwaters that historically provided wintering grounds for waterfowl and other wildlife along the Colorado River. Auto tour, boating, hiking, birding, fishing, horseback riding, photography. Free.  
• 3 Kofa National Wildlife Refuge (Along US 95, north of Yuma, south of Quartzsite; major entrances at Crystal Hill, Palm Canyon, King Valley, or the Castle Dome), ☏ +1 928-783-7861. Visitor Center: M-F 8AM-4:30PM; Lands, roads and trails: open daily, year-round w/ some temporary closures due to military range testing. Wildlife refuge and habitate of the Kofa Mountains. Hiking, backpacking, camping, biking, horseback riding, birding, hunting, photography. Free.  
• Vicksburg Rd (Exit 45). 
• Hovatter Rd (Exit 53). 
• Ave 75E (Exit 69). 
• Salome Rd (Exit 81). 
• Tonopah (Exit 94). 
• Wintersburg Rd (Exit 94). 

Greater Phoenix is a large conurbation of cities (municipalities) surrounding Phoenix in the middle of the state. Together, it is the Southwest's biggest metropolitan area with artsy urban communities, ritzy resorts, the country's largest university and resulting college town, beautiful desert wilderness on the outskirts and miles upon miles of suburban sprawl.

• 19 Buckeye

• 339th (Exit 103). 
• Sun Valley Pkwy, Palo Verde Rd (Exit 109). Location of Buckeye Airport (for general aviation) and the Lauridson Aviation Museum. The road becomes Palo Verde Rd south of I-10 and Sun Valley Pkwy north of the freeway. 
• to Gila Bend (Exit 112).  Signed " to Yuma, San Diego" from the WB lanes. Travelers coming from San Diego to Phoneix can come up north this way from I-8 in Gila Bend and continue east into Phoenix on I-10. Conversely other travelers coming from Los Angeles can exit from I-10 west of Buckeye, go south on AZ-85 to I-8, and continue east towards Tucson on I-8 and 10 via Casa Grande.

• 20 Goodyear
• 21 Avondale
• 22 Litchfield Park
• 23 Tolleson
• 24 Phoenix is the capital of Arizona with a vibrant downtown, active Latino communities in South Phoenix, artsy and young Roosevelt Street and the upscale Biltmore area. It is the 5th largest city in the United States and the primary political, cultural, economic, and transportation center of the southwest.

• Buckeye Rd; Sky Harbor; Rental Car Return (Exit 149). Go east on Buckeye Rd to get to the airline terminals and the Rental Car Center (RCC). This is also the location for Greyhound bus station. 

• 4 Phoenix Sky Harbor International Airport (PHX ^IATA). 

• North to Flagstaff (Exit 150, Eastbound exit only.). I-17 begins here from the eastbound lanes of I-10. I-17 goes along the south side of the downtown core and curves north west, of the state capitol district. It intersects I-10 again at Exit 143 (of I-10)/Exit 200 (I-17) west of downtown. 

• North Flagstaff West (Exit 150A); 24th St (Exit 150B) (Exits 150A/150B Westbound exits only.). I-17 begins from the westbound lanes of I-10 through Exit 150A. Westbound US Hwy 60 follows I-17 from here to Thomas/Grand Ave (Exit 201 of I-17). This also serves as a commercial truck route for I-10 truck traffic around downtown Phoenix. 

• 25 Tempe is a small but dynamic, steadily growing city. Its shared history with Arizona State University (ASU) has given it a long-standing reputation as a college town, and it is considered to be the academic and intellectual center of the greater Phoenix area. It is home to numerous research-centric industries in fields ranging from biotechnology to solar energy as well as a high percentage of knowledge workers those industries require.

• 43rd St, Broadway Rd (Exit 153). Eastbound exit only. Goes out to S 48th St/Hohokam Expressway. Go south (right turn) on S 48th to Broadway. 

• North Sky Harbor (Exit 153A); 52nd St, Broadway Rd (Exit 153B) (Exit 153A/153B). Westbound exit only. AZ-143 goes by the airport from the eastside (via Sky Harbor Blvd) and ends at AZ-202 past the airport. It also accesses W University Dr, Washington St and Van Buren St. 

• East Mesa, Globe (Exit 154). Going east US Hwy 60 goes towards Apache Junction as the Superstition Freeway with multiple exits to Tempe and Mesa. Going west, US Hwy 60 continues along I-10 and I-17 towards Grand Ave at Exit 201 of I-17. Prior to the existence of the Superstition Freeway (present day US Hwy 60) the old US Highways 60,70,80,89 ran concurrently and continuously on W Apache Trail (Apache Jct); Main St (Mesa) and E Apache Blvd (Tempe). The road then curves north on Mill Ave towards Papago Park and then westward from Papago Park, along Van Buren, towards Grand Ave at 7th Ave & Van Buren in downtown Phoenix. 
• Baseline Rd (Exit 155). Signed "Baseline Rd, Guadalupe" from the EB lanes. Local access to Arizona Mills Mall via Baseline from the freeway. Go south on Avenida de Yaqui from south of Arizona Mills Mall to get to Guadalupe. 

• 26 Guadalupe was founded around 1900 by Yaqui Indians, who fled their homeland in Sonora to avoid oppression by the Mexican government of Porfirio Diaz. Since its founding, it has been known as a center of Yaqui culture and it is home to many religious festivals. Respectful visitors are welcome to observe these ceremonies, although photography during ceremonies is forbidden.
• 27 Chandler
• 28 Sun Lakes

South Central Arizona have some of the beautiful high deserts, interesting cities and sparse wilderness. It includes the corridor (I-19) from Tucson to Nogales, the biggest port of entry in Arizona.

• 29 Casa Grande

• McCartney Rd (Exit 190). 
• Florence Blvd (Exit 194). 
• Jimmy Kerr Rd (Exit 198). 
• San Diego, Phoenix Bypass Route (Exit 199). I-8 begins/ends here. I-8 replaces or supersedes sections of the old Hwy 80 between Gila Bend and San Diego. There are sections of the old US Hwy 80 still there alongside of I-8 in some places along the way. Travelers coming from Tucson towards Los Angeles can go through I-8 to AZ-85 in Gila Bend. Go north on AZ-85 to Exit/Mile 112 of I-10, west of Buckeye, and continue westward towards Los Angeles from Buckeye. 

• 30 Eloy

• Sunland Gin Rd, Arizona City (Exit 200). 
• Toltec Rd (Exit 203). 
• Sunshine Blvd (Exit 208). 

• 31 Picacho

• Coolidge, Florence (Exit 211). 

• 1 Picacho Peak State Park

• Picacho Peak Rd (Exit 219). Main access to Picacho Peak State Park from the freeway. 

• 32 Tucson also known as the "Old Pueblo", is the second-largest city in the state of Arizona and the county seat of Pima County in the Sonoran Desert. It is at a higher elevation than nearby Phoenix and is correspondingly cooler.

View of Tucson towards the Santa Catalina Mountains

• Prince Rd (Exit 254). 
• Miracle Mile (Exit 255). AZ-77 (old US Hwy 80 and 89) continues north through/from Tucson on N Oracle Ave to Oracle Junction. The old US Highways 80 and 89 then follow AZ-79 from Oracle Junction through Florence, to US Hwy 60 in Florence Junction/Queen Valley where it continued west along US Hwy 60 to Apache Junction. 
• Grant Rd (Exit 256). 
• Speedway Blvd (Exit 257). 
• 29th-22nd St, Silverlake Rd, Starr Pass Blvd (Exit 259). 
• Nogales (Exit 260). I-19 begins and ends here. Follow I-19 to Exit 99 ( West Ajo Way) to get on AZ-86 going west to the southside of Tucson Mountain Park, Tohono O'Dham Indian Reservation and Ajo. I-19 ends at the Mexican border in Nogales, 64 mi (103 km) south. 
• 6th Ave, 4th Ave (Exit 261). The old US Hwy 80 and 89 went north along S 6th Ave, through South Tucson and downtown towards University Way. They turned left (west) on University and than right (north) on Oracle Ave (Az-77) where they continued north towards Oracle Junction. Going south the old US Hwy 80 followed E Benson Hwy and the present I-10 towards Benson while the old US Hwy 89 continued south on S 6th Ave which becomes S Nogales Hwy and then along the present I-19 towards Nogales from Exit 69 of I-19. US Hwy 89 now ends further north in Flagstaff. 
• Benson Hwy, Park Ave (Exit 262). 
• Ajo Way, Kino Pkwy (Exit 263). Access from westbound lanes only. Go south on Kino Pkwy to Benson Hwy. Follow Benson Hwy and than south on Tucson Blvd to get to the airport. 

• Kino Pkwy North South to Tucson Intl (Exit 263A); Kino Pkwy North Ajo Way (Exit 263B) (Exit 263). Access from eastbound lanes only. 
• 5 Tucson International Airport (TUS ^IATA). 

• Irvington Rd, Palo Verde Rd (Exit 264). 
• Alvernon Rd North (Exit 265). 
• Valencia Rd, Tucson Intl (Exit 267). Go west on Valencia Rd to Tucson Blvd. Go south on Tucson Blvd to get to the airline terminals. First exit to the airport for travelers coming from Benson or anywhere south/southeast of Tucson. Going west the old US Hwy 80 and the old AZ-86 followed E Benson Hwy from Valencia to 6th Ave south of Tucson. The old AZ-86 turned left (west) on Ajo Way while US 80 continued to old the US Hwy 89 on 6th Ave. AZ-86 ends at W Ajo Way and I-19 whereas it used to continue on E Benson Hwy and on the present I-10 to the New Mexico state line, concurrent with US-Hwy 80 to Benson. 

Southeast Arizona is a sparsely-populated, scenic region of the Sonoran desert with a number of historic sights and remote wilderness areas.

• 33 Mescal.  

• Mescal Rd/J Six Ranch Rd (Exit 297). 
• Skyline Rd (Exit 299). 

• 34 Benson.   – a historic rail town and convenient base.

• Ft Huachuca Sierra Vista (Exit 302). 
• to East Tombstone, Douglas (Exit 303). AZ-80/BL-10 go through town as 4th St. Historically the old US Hwy 80 follows present day AZ-80 to Douglas via Tombstone and Bisbee while I-10 follows the old AZ-86 to the New Mexico state line where it became the old (decommissioned) NM-14 to Roadforks. Since the completion of I-10, AZ-86 ends in Tucson (at W Ajo and I-19). 
• Ocatillo Ave (Exit 304). 
• to East Pomerene Rd, Tombstone (Exit 306). Signed "Pomerene Rd" from WB side. Pomerene Rd ends at 4th Ave (AZ-80) just south of the freeway. It's right turn from the eastbound lanes or a left from the westbound side. 
• Sibyl Rd (Exit 312). 
• Dragoon Rd (Exit 318). 
• Johnson Rd (Exit 322). 

• 35 Willcox – a historic town and gateway to Chiricahua National Monument.

• South Sunsites Douglas (Exit 331). NB US Hwy 191 follows I-10 east to Exit 352. 
• to East to Chiricahua National Monument (Exit 336). BL-10 (Old AZ-86) goes into town as Haskell Ave. 
• East Rex Allen Dr, Ft Grand Rd (Exit 340). Main exit into downtown Willcox. 
• to Old Stewart Rd (Exit 344). BL-10 (Old AZ-86) goes into town as Haskell Ave. 
• North Safford (Exit 352). SB US Hwy 191 follows I-10 west to Exit 331. From this exit, US Hwy 191 goes 39 mi (63 km) north to US Hwy 70 in Safford. 

• 36 Bowie (Exits 362 & 366). goes through town simply as "Business Loop 10", the main street of Bowie.  
• 37 San Simon (Exits 378 & 382). goes through town as 6th St.  

New Mexico

The maximum speed limit is 75 mph (120 km/h) for cars and trucks on rural stretches and 65 mph (104 km/h) in urban areas (through Las Cruces and Anthony) or lower if posted otherwise.

In New Mexico, I-10 follows the former path of U.S. Route 80 (US 80) across the state, although major portions of old US 80 were bypassed in Western New Mexico's Bootheel and Doña Ana Counties. I-10 passes through three Southern New Mexico municipalities of regional significance west of the junction with I-25: Lordsburg, Deming, and Las Cruces. Most of I-10 in New Mexico, between Exit 24 (Lordsburg) and Exit 135 (Las Cruces), is concurrent with US 70 and old US 80. The old US 80 leaves I-10 at Exit 116 and runs parallel as NM-549 34 mi (55 km) east of Deming. It goes alongside I-10 into Deming as Business Loop 10 (Pine St) and continues another 14 mi (23 km) west of Deming, alongside I-10, to Exit 68 as NM-418. Going west towards Arizona the old U.S. Route 80 diverges from I-10 at Road Forks (Exit 5) via NM-80 towards the Mexican border in Douglas, Arizona via Rodeo, New Mexico. The present I-10 continues west on the old NM-14 and AZ-86 from Road Forks (Exit 5) to Benson, Arizona (Exit 306) where the old US 80 (now AZ-80) rejoins the highway (concurrent with old AZ-86 on the present I-10) to Tucson.

• Business Loop (BL)-10 serves as an auxiliary road branching from the interstate through Las Cruces, Deming and Lordsburg as a local street. They replace a section of the old US highway (US Hwy 70, 80, 180) that once went through town as a local street.

I-10 traverses southern New Mexico through Hidalgo, Grant, Luna, and Doña Ana counties. The interstate travels west–east from the Arizona state line to the interchange with I-25 in Las Cruces, and then travels north–south to the Texas state line. US Route 80 in New Mexico (US 80) was replaced by I-10:

• Steins (Exit 3). Steins is a ghost town in Stein's Pass of Hidalgo County, New Mexico. It was originally called Stein's Pass after the nearby pass through the Peloncillo Mountains (Hidalgo County). The pass was named after United States Army Major Enoch Steen, who camped nearby in 1856, as he explored the recently acquired Gadsden Purchase. 
• Road Forks (Exit 5). The old U.S. Route 80 diverges (as NM-80) from the i-10 corridor and goes south towards Douglas, through Rodeo 
• Animas (Exit 11). 
• 38 Lordsburg - A tiny settlement along I-10 near the Arizona border; nearby are some ghost mining towns from Old West times.

• W Motel Dr (Exit 20/20B). Exit 20 from westbound side and 20B from eastbound side. Exit 20A goes into a rest area from the eastbound lanes only. 
• Main St (Exit 22). Main exit into Lordsburg. US 70 (west) winds its way to Globe through Stafford via Duncan Hwy, from Main St, north of town. Going east, US 70 follows I-10 to Exit 135 in Las Cruces. 
• E Motel Dr (Exit 24). 

• Playas (Exit 34). 
• 39 Deming - A small town along I-10 that has some interesting rock formations nearby and is home to an annual quirky "duck race."

• (Exit 68). NM-418 replaces a section of the old US Hwy 80 from Exit 68 into Deming (Exit 81), which runs alongside of I-10. Through Deming the old US Hwy 80 is BL 10 (Pine St) across town to Exit 85. 
• W Pine St (Exit 81). 
• West; East to  ; Silver City Hatch (Exit 82 (Gold Ave)). North of town splits with US 180 going 53 mi (85 km) northwesterly to Silver City while NM 26 goes 48 mi (77 km) northeasterly to I-25 in Hatch. Going east US 180 follows I-10 concurrently to El Paso. Going towards the south of town Gold Ave becomes Cody Rd which becomes Columbus Rd. It goes another 32 mi (51 km) south to Columbus near the Mexican border. Deming, the town itself is south of the freeway. 
• E Pine St (Exit 85). 
• Akela (Exit 102). 
• (Exit 116). NM-549 replaces a section of the old US Hwy 80 from Exit 116 to east of Deming (Exit 85) alongside I-10. In between it's also accessible from I-10 at Exit 102 in Akela. 

• 40 Las Cruces - The largest city in southern New Mexico, home to New Mexico State University, some historical attractions, and a gateway to the Organ Mountains east of town.

• Corralitos Rialtos Rd (Exit 127). 
• Las Cruces International Airport (Exit 132). 

• 6 Las Cruces International Airport (LRU ^IATA). Located 10 min west of downtown Las Cruces in West Mesa, the airport serves as a general aviation airport and for VIP flights. It also have ample facilities for unmanned Aerial activity, and testing and system development. Nearest airport for scheduled passenger airline services is El Paso International Airport, a 45-minute drive south from downtown Las Cruces on I-10. 

• W Picacho Ave (Exit 135). US Hwy 70 connects I-10 from west of Las Cruces towards Clovis through Alamogordo. It crosses through the westside of town as W Picacho Ave to Main St. It then goes northeasterly towards I-25 (Exit 6 of I- 25) on Main St. Going west it runs concurrent with I-10 from Las Cruces to Lordsburg. 
• Motel Blvd (Exit 139). 
• Ave Mesilla (Exit 140). 
• to Main St, University Ave (EB side); Valley Dr, University Ave (WB side) (Exit 142). go east on University Ave to get to the New Mexico State University campus. University Ave also connects to Exit 1 of I-25. 
• North to Albuquerque; East to El Paso; West to Las Cruces, Mesilla (Exit 144). Southern terminus of I-25. US Hwy 85 runs concurrently with I-25 through New Mexico and with I-10 into El Paso from Las Cruces. I-10 curves southward and merges into I-25 to continue towards El Paso (as I-10) while Exit 144 directs traffic into the northbound lanes of I-25. Coming from El Paso, Albuquerque is 223 mi (359 km) north of Las Cruces via I-25 and Santa Fe is another 62 mi (100 km) north of Albuquerque, Locally I-25 goes through the middle of Las Cruces, accessing most parts of the city. I-10 curves westward along the southside of town, the airport and the town of Mesilla. 
• Mequite (Exit 151). 
• Vado, Berino (Exit 155). 

• 41 Anthony, NM

• Anthony, Chaparral (Exit 162). 

Texas

The maximum rural speed limit is 85 mph (136 km/h) for cars and large trucks which is more relevant along State Highway (SH) 130 between Georgetown (north of Austin) and Seguin (east of San Antonio). The I-10 corridor between Hoodspeth and Kerr Counties is 80 mph (128km/h) in rural areas and 75 mph in urban areas or lower if posted otherwise. The remaining stretches of I-10 remain at 70-75 mph (112-120km/h) or as posted.

& US 90 begins at an intersection with BL I-10 (old US 80) and SH 54 in downtown Van Horn. It then heads south-southeast towards Marfa, where the route begins to head generally east/southeast towards Del Rio and then towards San Antonio via Uvalde. The route is mostly two lanes west of Uvalde. At this point, it becomes a four-lane surface road until it reaches western Bexar County where it becomes a freeway, joining I-10 in Downtown San Antonio. This concurrency with I-10 continues intermittently from San Antonio into western Houston, where US 90 follows the Katy Freeway. The section of US 90 that is multiplexed with I-10 through Houston is the only section of the route that is unsigned. In eastern Houston, US 90 splits from I-10 and heads northeast towards Liberty, eventually traveling through downtown Beaumont where it rejoins I-10 and go concurrently into Louisiana. US 90 between Van Horn and San Antonio replaces the third auxiliary option of the Old Spanish Auto Trail (OST-3). US 80 begins/ends at its junction with I-30 east of Dallas. The remaining sections of US 80 between Dallas and El Paso is replaced by I-20 & I-10.

The following highways replaced the main Old Spanish Auto Trail (OST-1) after 1927, between West Texas and San Antonio, which were eventually replaced or bypassed by Interstate 10 in phases after 1960:

• I-10 replaces sections of & between Jct I-20, Ft Stockton and Mountain Home (Exit 488). US Hwy 290 ends/begins at its junction with I-10 at Exit 477 (to Fredricksburg).
• & I-10 bypasses SH 27 and runs concurrently with US Hwy 87 between Mountain Home and San Antonio. Historically US 87 went from San Antonio to Comfort where it goes north to Fredricksburg while SH-27 continued northwesterly through Kerrville, Ingram and Mountain Home to Ft Stockton (paired with US Hwy 290). SH 27 is still there, alongside of I-10, between Comfort and Mountain Home ending at milepost 488 of I-10. US Hwy 87 goes south from Fredricksburg to Comfort where it continues concurrently with I-10 from Comfort to San Antonio (Roland Rd at Exit 577). Business Loop (BL)-US 87 serves as an auxiliary road branching from the main US Hwy 87 on the interstate through Boerne and Comfort as a local surface street.
• Business Loop (BL)-10 serves as an auxiliary road branching the from interstate through Sierra Blanca, Van Horn, Balmorhea and Ft Stockton as a local surface street. It often replaces an old US and/or state highway (US Hwy 80 & 290) that once went through a town as a local street. In Texas BL-10 is paired with a state (SH) or Farm to Market (FM) highway in some places.

Big Bend Country vast remote region of western Texas consisting of Big Bend National Park, mountains, desert and canyons.

• 42 Anthony, TX
• 43 El Paso - Largest city of the Trans-Pecos region, with a uniquely Mexican culture and the closest point to the Mexican border (at Ciudad Juarez) from the I-10 corridor.
• 2 Hueco Tanks State Historic Site
• 44 Sierra Blanca.  

• El Paso St (Exit 105). Business Loop (BL) 10 (old US Hwy 80 & TX-Loop 416) goes into town as El Paso St from the west end of town. 
• Sierra Blanca Ave (Exit 107). Serves as the main exit into downtown Sierra Blanca from both directions. 
• Sierra Blanca (Exit 108). Business Loop (BL) 10 (old US Hwy 80) goes into town as El Paso St from the east end of town. Accessible from westbound lanes only. 
• Allamore (Exit 129). 

• 45 Van Horn

• Golf Course Dr (Exit 138). Business Loop (BL) 10 (old US Hwy 80) goes into town as Broadway from Golf Course Dr, at the west end of town. 
• Van Horn Dr Dr (Exit 140A). US Hwy 90 begins/ends 3 blocks north at Van Horn Dr and Broadway (old US Hwy 80 & TX-Loop 519) in the middle of town. Going south, US Hwy 90 winds 304 mi (489 km) southeast towards Del Rio (at the Mexican border), through Valentine, Marfa, Alpine, Marathon and Sanderson. From Del Rio it goes another 156 mi (251 km) east, through Uvalde, to San Antonio where it merges with I-10, south of downtown San Antonio. 

• 3 Guadalupe Mountains National Park. is another 62 mi (100 km) north of Van Horn on TX-Hwy 54 at its junction with US Hwy 62. Likewise one can go 113 mi (182 km) east on US Hwy 62 from El Paso to reach Guadalupe Mountains National Park.  

• Ross Dr (Exit 140B). Business Loop (BL) 10 (old US Hwy 80) goes into town as Broadway from Ross Dr, at the east end of town. Broadway (old US Hwy 80) continues, alongside I-10, another 19 mi (31 km) east to Moon Rd in Plateau at Exit 159. 
• Wild Horse Rd (Exit 146). Moon Rd 
• Michigan Flat (Exit 153). Richard Kane Rd 
• Plateau (Exit 159). 

• , ; Kent, Ft Davis (Exit 176). 
• East to Dallas-Ft Worth; East to San Antonio, West to El Paso (Exits 186 & 187). Going eastbound (EB) the freeway continues onto I-20 while I-10 exits off to the right in a single lane to continue east. Going westbound (WB) on I-10 a single lane exits to the right to get onto I-20 east towards Dallas (Exit 187). There's a leftside exit (Exit 186) for westbound (WB) traffic of I-20 to to turn around and go EAST on I-10 while the rest of WB I-20 merges into WB I-10. Exit numbers only appear on the westbound side. Historically US Hwy 80 ran continuously through here between Dallas and Lordsburg, New Mexico via El Paso, now it truncates east of Dallas at its intersection with I-30. Travelers continuing east towards Arkansas and Tennessee would continue on I-30 from east of Dallas. (updated Apr 2024)
• 46 Fort Stockton

• Alpine, Sull Rose State University (Exit 248). US Hwy 67 goes 55 mi (89 km) south towards US Hwy 90 in Alpine. Going north, US Hwy 67 follows I-10 east to Exit 273. 
• Ft Stockton (Exit 256). Business Loop (BL) 10 (old US Hwy 290) goes through town as W Dickinson Blvd from the west end of town. 
• Pecos, Sanderson (Exit 257). 
• Monahans (Exit 259). Direct exit into downtown Ft Stockton as N Front St (TX-18). Going north, TX-18 goes 50 mi (80 km) to I-20 in Monahans. 

• (Exit 259A). Access to Imperial Hwy from the westbound lanes only. Access to Imperial Hwy from the eastbound lanes through Exit 259 and along the I-10 service road. 

• Ft Stockton, Marathon (Exit 261). Sign from the eastbound lanes simply reads "Marathon". Business Loop (BL) 10 (US Hwy 385 & old US Hwy 290) goes through town as E Dickinson Blvd from the east end of town. US Hwy 385 turn southwards, towards Marathon on W Railroad Ave. Going north, US Hwy 385 goes concurrently on I-10 to Exit 273. 
• McCammey, San Angelo (Exit 273). 

• 4 Fort Lancaster State Historic Site, 629 Fort Lancaster Road, Sheffield (80 miles east of Fort Stockton, 35 miles west of Ozona), ☏ +1 432-836-4391. Daily 9AM-5PM. Ruins of an 1850s frontier fort that protected the wagon trail from San Antonio to El Paso. Visitor center with displays, exhibits, and merchandise. $5 a person. (updated Aug 2018)

• Iraan, Sheffield (Exit 325). If coming from the west, go south on TX-349 to Sheffield and than TX-290 to Ft Lancaster 
• Co Road 307 (Exit 328). 
• Co Road 305 (Exit 337). 
• West (Exit 343). If coming from the east, TX-290 serves as the most direct way to Ft Lancaster. Not signed from the westbound lanes except for 'EXIT 343' at the off-ramp. 

The Hill Country is a region of the state of Texas in the United States of America. It has some of the most interesting history of the state. The cities here date to Spanish and Mexican days, with many beautiful Spanish missions dotting the area. The terrain is hilly and dry, cut by spring-fed rivers, with the beautiful Texas live oak providing occasional shade.

• Fredericksburg (Exit 477). Travelers going to Austin from the west can exit here and go east on US Hwy 290, through Fredericksburg. US Hwy 290 does continue east from Austin to Houston thus avoiding a drive into San Antonio. 
• 47 Ozona
• 48 Sonora
• 49 Kerrville - Home of one of the country's largest folk festivals.
• 50 Comfort
• 51 Boerne
• 52 San Antonio is the second largest city in the state of Texas and the 7th largest in the United States. It's the 24th largest metropolitan area in the country. Visited by more than 31 million annual visitors, San Antonio is a beautiful city at the axis of three different geological terrains: Hill Country, South Texas Plains and Prairie and Lakes. There's a lot to do in this city: fine art museums, historical missions and plenty of amusement parks in addition to great dining and lots of drinking. The culture and people are vibrant and interesting. San Antonio's downtown is one of the most lively in the nation.

• (Exit 564 of I-10; Exit 15 of I-410). The airport is 6 mi (9.7 km) east/northeast of its interchange with I-10 at Exit 21B from the eastbound lanes of 410 and Exit 21 from the westbound lanes. 

• * 7 San Antonio International Airport (SAT ^IATA)

• North to Austin; South to Laredo, East to Houston (Exit 570 of I-10 EB). Two left lanes exit off through the left towards I-35 NB while the other lanes (of I-10) merge into I-35 south towards US Hwy 90 at Exit 153 of I-35. 

• West North El Paso; North to Austin (Upper Level); (Lower Level) Corpus Christi, Johnson City (Exit 156 of I-35 NB). I-10 runs concurrently on I-35 between the US Hwy 90 interchange at Exit 153 to where I-10 continues west towards El Paso from Exit 156. Going east I-10 runs concurrently on US Hwy 90 towards Seguin. 
• East & South to Houston; West to Del Rio (Exit 153 of I-35 SB). 

• North to Austin; South to Laredo, West to El Paso (Exit 572 of I-10/US Hwy 90). I-10 exits off onto I-35 north towards Exit 156 of I-35. 

The Prairies and Lakes Region is located in the north central part of Texas. It is home to the Dallas-Fort Worth Metroplex, the fourth largest metropolitan area in the United States. This region also has a beautiful countryside with ranches, "bed and breakfasts", and many recreational lakes. Whether you're looking for the excitement of a big town (shopping, dining, nightlife), or for a more leisurely time in the rural areas, you'll find it here in the Prairies and Lakes Region.

• 53 Seguin
• 54 Luling
• 55 Gonzales - "The Birthplace of Texas Independence" Historical sites, festivals, good eats, and shopping
• 56 Schulenburg
• 57 Weimar

The Texas Gulf Coast stretches for hundreds of miles, from the Louisiana border to Brownsville on the Rio Grande. The beaches are excellent, and oil-rich cities like Houston make for fun nightlife, too.

• 58 Brookshire
• 59 Katy
• 60 Houston is a sprawling port city in Southeastern Texas. An oil boom and continuing international immigration has brought explosive growth to the city, and it is now the fifth largest metropolitan area in the United States. While at first glance, the city appears to be a 9-5 central business district surrounded by a sea of suburbs and strip malls, there are many hidden gems to be discovered.
• 61 Sugar Land
• 62 Baytown
• 5 San Jacinto Battleground State Historic Site.  
• 63 Stowell
• 64 China
• 65 Beaumont
• 66 Port Arthur

Louisiana

The maximum rural speed limit is 75 mph (120 km/h) for cars and large trucks which is more relevant along Interstate 49. The I-10 corridor remains at 70mph (112 km/h) in rural areas and 60 mph in urban areas or lower if posted otherwise.

Entering Louisiana from the west, US 90 and I-10 travel side by side through Lake Charles to Lafayette. In Lafayette, US 90 and I-10 part ways: I-10 proceeds east to Baton Rouge, while US 90 takes a southern turn and passes through New Iberia, Franklin, Morgan City, and Raceland in the Bayou Cane – Thibodaux metropolitan area before reaching New Orleans. It bypasses Houma north of town. LA-182 carries much of the Old Spanish Trail (OST) from before 1930, which closely parallels US 90, between Lafayette and Raceland as a separate road through the same cities and towns including through Houma. After 1930 the OST was re-aligned to US Hwy 90. All iterations of the OST include crossing the Huey P Long Bridge into and out of New Orleans.

Southwest Louisiana is the vibrant "Heel of the Boot" in the southwestern corner of Louisiana. It is a land of contrasts: bountiful culture, amazing food, and colorful annual festivals that get bigger every year; but the Southwest also has a quickly vanishing coastline and equally quick vanishing wetlands environment. It is considered one of the fastest disappearing landscapes on Earth, with some studies showing that it has lost land area in the several of hundreds of square miles. This is a place where sea and land mingle together, and can be seen through the amazing refuges and nature sanctuaries in this area of the state. From the urban center of Lake Charles to the "Louisiana Outback" of Cameron Parish, this unique region has something for all visitors:

• 67 Vinton - The "Gateway to Louisiana," first Louisiana town just after the Texas state line with a few locations for outdoor activities, eats, and lodging, as well as a racetrack casino and a few small video poker rooms.
• 68 Sulphur - Industrial yet appealing place.
• 69 Lake Charles - The regional hub and only metro area. Parish seat of Calcasieu Parish and a regional center for gambling. Lady luck often strikes at three separate casinos in the area!
• 70 Jennings - The seat of Jefferson Davis Parish and the original Louisiana oil town, "black gold" was discovered here and a well put up in 1901.
• 71 Lake Arthur - A handsome town on the lake of the same name, with fishing and boating being the most popular activities. Birding is also popular at the nearby Lacassine National Wildlife Refuge.

South Central Louisiana is a part of "Acadiana," the name given to the region of southern Louisiana that is the home of the Cajun (or "Acadian" as they were originally known) people. Everything that made Cajun culture popular came from this region: food, music, literature, and of course, the unique variant of French spoken here. This particular area, along with the Cajun Prairie, is effectively an enclave in the southern United States: an area that is predominantly French in background and culture, but still distinct from French culture in Metropolitan France or Quebec:

• 72 Henderson
• 73 Crowley
• 74 Rayne
• 75 Scott

• Crankton Scott (Exit 97). 

• 76 Lafayette. is a city in Louisiana. It's the unofficial capital of Acadiana or Cajun Country. This flourishing moderate sized city is home to the University of Louisiana at Lafayette. Music and dancing is an integral part of community life. Several restaurants and dance halls thrive in the area and the city hosts several musical festivals throughout the year.  

• Ambassador, Caffrey Pkwy (Exit 100). 
• N University Ave (Exit 101). 
• North to Opelousas (Exit 103B); South to Morgan City (Exit 103A) (Exit 103). Going south of I-10, US Hwy 167 connects travelers to US Hwy 90 where it takes a southern turn and passes through New Iberia, Franklin, Morgan City, and the Houma – Bayou Cane – Thibodaux metropolitan area before reaching New Orleans. Going west of its junction with US Hwy 167, US Hwy 90 closely parallels I-10 through Scott, Rayne, Crawley, Jennings and Lake Charles to the Texas state line. Going north, US Hwy 167 becomes I-49. 
• Louisiana Blvd (Exit 104). 

• 77 Breaux Bridge — the largest city in St. Martin Parish

• Breaux Bridge (Exit 109). 

• 78 Henderson

The River Parishes are the Louisiana parishes that line the Mississippi River in the eastern part of Acadiana, from the Mississippi state line to just outside the New Orleans metro area. From Baton Rouge north, the parishes are on the west bank of the river (we have placed Baton Rouge in the Florida Parishes). The parishes between Baton Rouge and New Orleans straddle the river and, in particular, form a unique area known as the "Acadian Coast." This was an area that the first Acadian (now Cajun) exiles settled when they arrived in Louisiana from Canada.

I-10 crosses over the Mississippi River into Baton Rouge

• 79 Baton Rouge – The state capital

• to to Lobdel (Exit 151). 
• Port Allen, Plaquemine (Exit 153). 

Crosses the Mississippi River.

• to LSU, Nicholson Dr, Highland Rd (Exit 155A). Exit from EB side only, return to WB side only 
• Downtown, Metro Airport (Exit 155B). Additional downtown exit via I-110 
• Washington St (Exit 156A); Louise St (Exit 155C) (Exit 155C, 156A). Exit 156A is accessed from the eastbound side while 155C is only accessed from the westbound side. Both land in the general vicinity of each other. 
• Dalrymple Dr, LSU (Exit 156B). 

Crosses City Park Lake

• Perkins Rd (Exit 157A). Exit from and return to eastbound lanes only. 
• Acadian Thruway (Exit 157B). 
• College Dr (Exit 158). 
• East to Hammond (Exit 159); East to New Orleans (Exit 159). Three left lanes of the freeway continue east as I-12 while the right two lines curve right (south)as I-10 towards New Orleans 

• 80 LaPlace

• La Place (Exit 206). 
• Hammond, La Place (Exit 209). Southern terminus of I-55 and US Hwy 51. Going north US Hwy 51 runs concurrent with I-55 to I-12 in Hammond where it splits into a separate road but remains alongside or (or concurrent in some places with) I-55 to Memphis, Tennessee where they go in separate directions. I-55 follows alongside US Hwy 61 from Memphis, through St Louis, to their northern terminus in Chicago. Going south US Hwy 51 continues past I-10 and ends at its intersection with US Hwy 61 in w:La Place while I-55 ends at I-10. 

• South to Boutte Houma (Exit 220). connects the I-10 corridor to: 

• 81 Luling
• 82 Saint Rose

Greater New Orleans is a region centered on New Orleans, Louisiana's biggest city and top visitor attraction, and encompassing the south east part of the state, including the lower Mississippi River, smaller cities and towns, bayous, wetlands, and nature preserves:

• 83 Kenner

• Loyola Dr, N.O. Intl Airport (Exit 221). 

• 8 Louis Armstrong New Orleans International Airport ((MSY ^IATA)). The old terminal at the southeast end of the runways is replaced by a new terminal at the opposite side of the runways since Nov 2019. It is directly linked by Loyola Dr from I-10 (Exit 221). Plans are underway for the future use of the old terminal but the car rental center is still next to the old terminal for car rental returns. 

• Williams Blvd, N.O. Intl Airport (Exit 223, Rental Car Returns). Travelers coming from the westbound lanes can get on the (old) Airport Access Rd to the old terminal for rental car returns. Access from the eastbound lanes only goes into Williams Blvd (LA-49) which parallels to the Airport Access Rd to the old terminal. The new rental car parking garage is next to the old airline terminal, follow signs. Access to the new airline terminal is via Loyola Dr at Exit 221. 

• 84 Metairie
• 85 Jefferson
• 86 New Orleans In New Orleans you'll find the roots of jazz and a blossoming culture that is unlike anything else on Earth. Here, the laid-back atmosphere of the riverfront South has mixed with French sophistication, Spanish style, and African-American energy to create something greater than the sum of its parts. Though hit hard by Katrina, "NOLA" remains the largest city in Louisiana and one of the top tourist destinations in the United States.
• 87 Slidell

Mississippi

The maximum speed limit is 70 mph (112 km/h) for cars and trucks on rural stretches and 60 mph (100 km/h) in urban areas or lower if posted otherwise.

US Highway 90 serves the main highway through major cities and towns of the Mississippi Gulf Coast while I-10 runs parallel with US Hwy 90 to serve as the main bypass route. There are various north-south roads that connect I-10 to the Mississippi Gulf Coast.

• 88 Waveland

• NASA John C. Stennis Space Center, Waveland (Exit 2). MS-607 connects into US Hwy 90 west of Waveland. 

• 89 Bay St Louis - despite taking a hard hit from Hurricane Katrina, the town still has lots of charm and a local art scene.

• Bay St Louis, Kiln, Picayune (Exit 13). MS-603 provides for a more direct access to Waveland and Bay St Louis from I-10. 

• 90 Diamondhead (Exit 16).  
• 91 Pass Christian

• De Lisie Pass Christian (Exit 20). Pass Christian is 8.5 mi (13.7 km) south of this exit, through De Lisie and the Wolf River Marsh Reserve, on Kiln-DeLisie Rd 
• Menge Ave (Exit 24). 

• 92 Gulfport - Mississippi's 2nd largest city is on the coast.

• Canal Rd (Exit 32). serves as the western city limits boundary of Gulfport. 
• South to Gulfport (Exit 34A); North to Hattiesburg (Exit 34B) (Exit 34). US Hwy 49 goes to US Hwy 90 in Gulfport as 25th Ave 

• 9 Gulfport-Biloxi International Airport (GPT ^IATA). Go left (east) on Airport Rd from US Hwy 49 to get to the airport. The Gulfport-Biloxi International Airport serves as the major airport in the Mississippi Gulf Coast. 

• Lorraine Cowan Rd, (Exit 38). Goes into the Bernard Bayou Industrial District east of town. 

• 93 Biloxi

• Shriners Blvd, Woolmarket (Exit 41). 
• Cedar Lake Rd, Coast Coliseum (Exit 44). 

• 94 D'Iberville

• Gallery Pkwy (Exit 46A). Access from eastbound lanes only. Entry to westbound lanes only. 
• South to Biloxi, Kissler AFB (Exit 46B). I-110 connects I-10 to downtown Biloxi. There are additional exits to D'Iberville along I-110 between I-10 and Biloxi Bay. 
• North (Exit 44C). Going north past I-10, I-110 becomes MS-15 & 67 which split in two separate directions. 
• Lamey Bridge Rd (Exit 46D). Access from westbound lanes only. Entry to eastbound lanes only. 

• 95 Ocean Springs

• South to Ocean Springs (Exit 50). MS-609 goes to US Hwy 90 in Ocean Springs as Washington Ave 
• Gautier Ocean Springs (Exit 57). Goes 4 mi (6.4 km) miles south to US Hwy 90 just east of Ocean Springs. Go east on US Hwy 90 to get to Gautier. Going north on MS-57, it goes another 50 mi (80 km) to McClain. 

• 96 Gautier

• "Gautier" (Exit 61). Go south 3.5 mi (5.6 km) miles on Gautier-Vancleave Rd to US Hwy 90 just west of Gautier. Go another 3 mi (4.8 km) east on US Hwy 90 to get to Gautier. Signed as "Gautier Vancleave" from the westbound lanes. 

• 97 Moss Point and 98 Pascagoula

• East Moss Point; East Pascagoula (Exit 69). The freeway passes through Moss Point. MS-63 passes through Moss Point to the industrial eastside of Pascagoula which is south of US Hwy 90 
• Moss Point, Pascagoula (Exit 68). The freeway passes through Moss Point. 
• Franklin Creek Rd (Exit 75). Westbound travelers entering the state from Alabama can quickly access US Hwy 90 through here and proceed on US Hwy 90 through several cities/towns listed above. 

Alabama

The maximum speed limit is 70 mph (112 km/h) for cars and trucks in rural and urban areas or lower if posted otherwise.

U.S. Route 90 is internally designated by the Alabama Department of Transportation as State Route 16 (SR 16) (not signed), as a major east–west state highway across the southern part of state along the Gulf coast. Although not signed, SR-16 may appear to run concurrent on US 90 on some maps. US 90/SR 16 crosses the extreme southern part of the state, covering approximately 70 mi (110 km). The routes pass through Baldwin County before entering the city of Mobile where it gains a wrong way concurrency with US 98. and later joins US Truck Route 98, briefly also overlapping Interstate 165. The portion of US 90 that crosses Mobile Bay is locally referred to as the "Causeway". With the completion of I-10, US 90/SR 16 serves primarily as a local route connecting the towns along its path.

I-10 is the primary east–west highway of the Gulf Coast region of Alabama. The highway connects Mobile, the largest city in South Alabama, with Pascagoula, Mississippi, to the west and Pensacola, Florida, to the east. Within the state, the highway connects Mobile and Mobile County with the Baldwin County communities of Daphne and Fairhope.

I-10 Downtown Mobile

• 99 Mobile is a historic, diverse port city with a strong southern culture and heritage. The original capital of French Louisiana, Mobile is home to the oldest Mardi Gras celebration in the United States. It is Alabama's only major port and largest city near the Gulf Coast.

• To Montgomery (Exit 20). The south end of I-65 
• Dauphine Island Pkwy (Exit 22). 
• Michigan Ave (Exit 23). local access to the Mobile Aeroplex which is a general aviation airport and an industrial complex. 

• 99 Daphne & Spanish Fort

Crosses the Perdido River into Florida.

Florida

The maximum speed limit is 70 mph (112 km/h) for cars and trucks on rural stretches and as posted in urban areas.

US Highway 90 serves as an auxiliary route of I-10, passing through the county seats of all 15 counties on its course in the Florida Panhandle, and it is also the road upon which many of the county courthouses are located. It is never more than six miles (9.7 km) from Interstate 10 (I-10) throughout the state. It runs as a two-lane highway through most of the sparsely populated inland areas of the Florida Panhandle, widening to four lanes through and near several towns. The speed limit is 55 mph (89 km/h) for all rural points west of Monticello, and it is 60 mph (97 km/h) on all rural points beginning in Madison County to Glen St. Mary. The route also serve the major cities which are also county seats in Pensacola (Escambia County); Tallahassee (Leon County & state capital); Lake City (Columbia County) and Jacksonville (Duvall County).

• also known as Atlantic Boulevard in Jacksonville, is a major east–west state highway through the Florida Panhandle as an internal designation (with Florida Dept. of Transportation) for U.S. Highway 90. Therefore, mostly unsigned in favor of U.S. Highway 90, it runs from the Alabama state line (Perdido River) to Atlantic Beach. The only sections that are not signed as US 90 are north of Pensacola, where US 90 uses SR 10A and SR 10 is signed as U.S. Highway 90 Alternate, and east of south Jacksonville, where US 90 uses unsigned SR 212. SR 10 is also signed on Atlantic Boulevard in Jacksonville.
• is an internal designation for I-10 by the Florida Department of Transportation. It is unsigned but may appear to run concurrent with I-10 on some maps.

The highway runs east from the Alabama border on the Perdido River, through the Florida Panhandle and North Central Florida, serving the major cities of Pensacola, Tallahassee, Lake City, ending at Jacksonville:

• 99 Pensacola is a historic beach city in Escambia County, Florida's westernmost county, at the tip of the "panhandle". The city is home to the Pensacola Naval Air Station, the National Museum of Naval Aviation and many historic districts that skirt the downtown area. Surrounded on three sides by water, the Pensacola area is full of history, shipwrecks, beaches and spectacular vistas.
• 99 DeFuniak Springs is 3 mi (4.8 km) north of the freeway. DeFuniak Springs is a city of 7,000 people (2019) on the Emerald Coast of Florida. DeFuniak Springs is home to Lake DeFuniak, one of two spring-fed lakes in the world that is nearly perfectly round. The surrounding landscape around the lake is often decorated for the holidays between Thanksgiving and New Year's to celebrate.

• DeFuniak Springs, Freeport (Exit 85). Freeport is 16.5 mi (26.6 km) south of DeFuniak Springs on US Hwy 331. 

• 6 Choctawhatchee National Forest
• 99 Marianna
• 7 Apalachicola National Forest
• 99 Quincy

• Quincy (Exit 181). 

• 99 Tallahassee is the capital city of Florida, and the largest city in the Florida Panhandle region of the state. In addition to housing the state government, it is a university town home to Florida State University, Florida A&M University, and Tallahassee Community College. Tallahassee has a good selection of restaurants for a city of its size. The universities' theater, art, and music programs, in addition to an active Council of Culture and Arts, also make for an unusually vibrant arts scene.

Florida's Capitol Building (tower) stands behind the old Capitol in Tallahassee

• Quincy, Tallahassee (Exit 192). A section of US Hwy 90 between Quincy and Tallahassee. Travelers going to Tallahassee from further west can exit at 199 and follow US Hwy 90 into downtown Tallahassee or towards Quincy from the east. 
• Capital Circle Nw, International Airport (Exit 196). Capital Circle (FL-263) provides the most direct way to the airport from I-10 which is another 6.5 mi (10.5 km) south of this exit. 

• 10 Tallahasse International Airport (TLH ^IATA). 

• Monroe St, State Capitol (Exit 199). Monroe St goes north-south into downtown 
• Thomasville Rd/Capital Circle NE (Exit 203). Go Sw on Thomasville Rd (FL-61) to get into downtown without going to Monroe St. 
• West Tallahassee (Exit 209A); East Monticello (Exit 209B) (Exit 209A/209B). A section of US Hwy 90 between Tallahassee and Monticello through two separate exits from both directions. Travelers going to Tallahassee from further east can exit at 209A and follow US Hwy 90 into downtown Tallahassee (location of state capitol). 

• 99 Monticello
• 99 Greenville
• 99 Madison
• 99 Live Oak

• Lee, Live Oak (Exit 275). Section of US Hwy 90 between Lee and Live Oak. Ideal exit to take, to get into Live Oak from the west. 
• Live Oak, Jasper (Exit 283). 

• 99 Lake City

• North to Valdosta (Exit 296A); South to Tampa (Exit 296B) (Exit 296). Interstate route towards Tennessee via Atlanta. Going south this also the shortcut towards the Miami/Fort Lauderdale metro area in South Florida via Ocala and Orlando without going to I-95 in Jacksonville from the west. Local access to Lake City is at US Hwy 90 at exit 427 of I-75. 
• Lake City, White Springs (Exit 301). 
• Lake City, Fargo (Exit 303). US 441 goes through Lake City as Marion Ave. Travelers going into Osceola National Forrest from I-10 west of Lake City can exit through here and go south US Hwy 441 to NE Gum Swamp Rd in Five Points. Go east on NE Gum Swamp road into Osceala National Forest. 

• 4 Osceola National Forest is in the northeastern portion of Florida between Lake City and Jacksonville near the crossroads of I-10 and I-75 and the crossroads of US 90 and US 441. It is located in parts of Columbia, Baker, Bradford, and Hamilton counties. The forest is headquartered in Tallahassee, but there are local ranger district offices in Olustee.

• Sanderson, Olustee (Exit 324). Section of US Hwy 90 between Sanderson and Lake City. Access to Osceola National Forest through Sanderson or Olustee from US Hwy 90. Westbound travelers from further east can make an exit through here to get to Lake City or get on I-75 south from Lake City. I-10 passes through Osceola National Forest but there are no direct exits into Osceola National Forest from I-10. Travelers would have to exit here or the next one at US Hwy 441 to get into Osceola National Forest. 

• 99 Jacksonville occupies one of the most coveted spots on the Atlantic coast. Set amongst abundant beaches and possessing an ideal subtropical climate, its crown jewel is the unique habitat and natural beauty of the St. Johns River. For this reason and more, "The River City" is a popular destination for vacationers looking for a laid-back Sunshine State escape.

I-10 westbound at the interchange with US 17.

• Baldwin Starke (Exit 343). 
• Cecile Commerce Pkwy; to Beaver St (Exit 350). 
• Chaffee Rd (Exit 351). 
• Marietta/Hammond Blvd (Exit 355). 
• North to Savannah; South to Daytona Beach (Exit 356 of I-10; Exiit 21 of I-295). If getting on I-95 from this point or anywhere west this would be the exit to take to avoid heavier traffic nearer to downtown Jacksonville.Travelers coming from the west can go on I-295 north to Exit 33 of I-295 (Duvall Rd/Int'l Airport Blvd) to reach the airport. 
• Lane Ave (Exit 357). 
• Cassat Ave/Edgewood Ave (Exit 358). 
• Luna St to Lenox Ave/Highway Ave (Exit 359). WB Exit only. EB Entry only. 
• McDuff Ave (Exit 360). 
• South to Roosevelt Ave, NAS Jax (Exit 361). Access from westbound lanes only. 
• Stockton St/Riverside (Exit 362). 
• North to Downtown Jacksonville, Savannah; South to Jax Beaches, Daytona Beach. Interstate 10 ends at its junction with I-95. Follow I-95 south to cross over the St Johns River Bridge and take the next exit (#350B) to continue east on US 90 (Beach Blvd) towards Jax Beaches or onto US 1 south towards Daytona Beach. The below is a partial list of exits as seen from I-95 in both directions to access I-10 and the airport. 

• Gary St to Palm Ave to Marco Blvd (Exit 350B from I-95 Southbound lanes). 
• Atlantic Blvd Phillips Hwy (Exit 350A from I-95 Southbound). Travelers going towards St Augustine can continue south on I-95 or follow the Old Spanish Hwy onto the Phillips Hwy (US 1). US 90 serves as a continuation (of I-10) towards the Atlantic Coast on Atlantic Blvd. 
• Park St (Exit 351A from I-95 Northbound). Local exit into downtown Jacksonville from the northbound lanes of I-95 just north of the St Johns River. Downtown Jacksonville is accessed from Exits 351A through 354 of I-95. 
• Lake City (Exit 351B from I-95 Northbound). Beginning of I-10 from the Northbound lanes of I-95. From the southbound lanes I-10 is accessed via collector distributor lanes accessed from Exits 351A & 352 which is also tied to additional exits to local roads. Follow the " Lake City" signs to get onto I-10 from I-95. 
• 11 Jacksonville International Airport (JAX ^IATA) (Located at Exit 363/363B (Airport Rd) of I-95 and Exit 33 (Int'l Airport Blvd/Duvall Rd) from I-295. Approx 13 mi (21 km) north of Interstate 10.). 

Alternative routes

• U.S. Highway 90 predates Intestate 10 between San Antonio, Texas and Jacksonville, Florida while U.S. Highways 80 and 60 predates I-10 from West Texas to Los Angeles via Phoenix to complete the coast to coast route. With the completion of the interstate highway system, I-10 supersedes US 90 from San Antonio to Jacksonville while US 80 was decommissioned west of Dallas in favor of Interstates 8, 10 and 20 with the sections of the Old US Hwy 80 re-numbered as Business Loop (BL) 10 or to various state highways. US Hwy 90 begins/ends in Van Horn, Texas. It then heads south-southeast towards Marfa, where the route begins to head generally east. The route is mostly two lanes west of Uvalde. From Uvalde, it becomes a four-lane surface road until it reaches western Bexar County where it becomes a freeway, joining I-10 in Downtown San Antonio.
• Interstate 8 branches from I-10 in Casa Grande, Arizona and go west 348 mi (560 km) towards San Diego, through Gila Bend, Yuma and El Centro/Calexico. Travelers coming from San Diego on I-8 to Phoenix can go north on AZ-85 or the old U.S. Route 80 from Gila Bend to Buckeye and than continue east on I-10 into Phoenix. Westbound travelers from Tucson can do likewise from Casa Grande to Gila Bend, go north on AZ-85 or the old US 80 to Buckeye, and then continue west towards Los Angeles. I-8 replaces the old U.S. Hwy 80 from Gila Bend to San Diego.
• Interstate 12 serves as an auxiliary route, spanning along the northern shores of Lakes Maurepas and Pontchartrain to bypass New Orleans. It branches from I-10 in Baton Rouge, goes through Hammond and rejoins I-10 and I-59 in Slidell 91.5 mi (147.3 km) later. US 190 closely parallels I-12 most of the way between Baton Rouge and Slidell.
• & I-20 begins at I-10 in West Texas and it goes towards I-95 in Florence, South Carolina 1,539 miles (2,477 km) later. Going east from Dallas, Texas, US Hwy 80 closely parallels or runs concurrently on I-20 to Cuba, Alabama where I-20 and US 80 split towards separate directions. I-20 continues northeasterly towards Florence, South Carolina while US Hwy 80 goes southeasterly to Savannah, Georgia. Going west US 80 truncates east of Dallas while Interstates 20, 10, and 8 continue the rest of way towards San Diego.

Sections of the old US 80 through some cities and towns in Arizona, New Mexico, California, and Texas west of San Antonio have become business loops 10 through town from the interstate as a local surface street. Between the cities and towns in these states the old US 80 runs parallel alongside I-10 & I-8 as a separate two-lane road. Some have been re-numbered as a state highway while others are locally named "Old US Highway 80" or by a local designation.

Sections of the old US 60 through some cities and towns in Arizona and California west of the US 60 interchange in Brenda have become Business Loop 10 through town from the interstate as a local surface street. For the most of the way the old US 60 runs concurrently on I-10 between Brenda, AZ and Beaumont, CA. From Beaumont, CA-60 (old US 60) continues into Los Angeles as a separate highway.

• Federal Highway 2 is an east-west highway in Mexico that connects Tijuana in the Pacific Coast to Mexicali, San Luis Rio Colorado, Nogales and Ciudad Juarez along the US/Mexican border. It picks up again from Ciudad Acuna near the southern shores of La Amistad Lake Reservoir and continues along the Mexican side of the Rio Grande through Pierdas Negras, Nuevo Lardo, Reynosa, Matamoros and then ends at Playa Baghdad where the Rio Grande flows out into the Gulf of Mexico. This highway is a 2 lane highway that closely parallels Interstates 8 and 10 from the Mexican side of the border.

Stay safe

Being in warm climates rattlesnakes, cottonmouth snakes and other poisonous snakes can be found hiding in the shade and in/under vegetation. They can even by inside the restroom buildings or under parked vehicles too! Signs have been posted at the highway rest stops, campgrounds and trails to warn travelers on the presence of snakes.

Go next

• A Taste of Coastal Texas
• Easy Rider is a 1969 road movie starring Peter Fonda, Dennis Hopper, and Jack Nicholson, about a motorcycle ride from Los Angeles to New Orleans. The film is a canonical work of the postwar biker and hippie cultures, and revived the Harley-Davidson motorcycle as an icon of freedom. The route does not closely follow I-10 but rather serves as an alternate route to I-10 between Needles, California and Las Vegas, New Mexico. It follows US Hwy 90 (OST) between Franklin, Louisiana and New Orleans.
• The Jazz Track is an itinerary for visiting jazz-related places (particularly big band and traditional jazz) in the United States. Along I-10 New Orleans is one of several jazz related places mentioned in the article.
• US Highway 1 predates the interstate highway system (Interstate 95) still in existence along the eastern seaboard. It connects Fort Kent, Maine in the north to Key West, Florida in the south. It intersects I-10 in Jacksonville.
• Pacific Coast Highway and El Camino Real are a couple of itineraries exploring the coastal regions of California from the western terminus of I-10 in Santa Monica, California.
• Interstate 5 (Old U.S. Hwy 99) The old US Hwy 99 followed US Hwy 60 & 70 (now I-10) from Downtown Los Angeles to Indio, California where it continued southward along the western shores of the Salton Sea towards the Mexican border in Calexico along CA-86. Between Brawley, California and the Mexican border in Calexico the old US Hwy 99 followed CA-111. Going north from Los Angeles Interstate 5 replaces the old US 99 from Los Angeles to Vancouver BC. Going south, I-5 (formerly US 101 from before 1960) continues to the Mexican border in San Ysidro via San Diego and Orange County. It intersects I-10 in downtown Los Angeles.
• Mississippi River
• Pan American (PanAm) Highway spans from the northern coast of Alaska to the Darien Gap in Panama with the all the interstate highways designated as the "pan-american highway" in the U.S. (Lower 48). Interstate 10 from Goodyear to Tucson serves as a part of the CANAMEX_Corridor, a variation of the Pan-Am Highway from the southern end of the Alaska Highway in Dawson Creek, BC; through Alberta, the United States and eventually into Mexico City. The section of Interstate 10 between El Paso and Las Cruces is also a part of the CanAm Highway, another variation of the Pan American Highway which connects El Paso at the Mexican border to northern Saskatchewan in Canada by way of I-25/US Hwy 85 in the U.S., and a variety of provincial highways through Saskatchewan.

• Camino Real de Tierra Adentro is the historic Spanish silver mining route, a 2,600 km route from Mexico City, through northern Mexico, into the United States, ending in Santa Fe, New Mexico. US Hwy 85, as mentioned in the article, serves as the conduit for El Camino Real de Tierra Adentro in the United States. Between El Paso and Las Cruces US Hwy 85 runs concurrent on Interstate 10 and concurrent on I-25 between Las Cruces and Denver, through Albuquerque and Santa Fe. The route is a UNESCO World Heritage Site route.

• Route 66 (aka Old US 66) was a highway that extended from Chicago to Los Angeles. It crossed much of the American Midwest, Great Plains, and Southwest. Although Highway 66 is no longer commissioned as a US Highway, it represents a multitude of ideas: freedom, migration West, and the loneliness of the American heartland. More than four-fifths of it remain drivable (though not always well-marked) as a collection of state highways and local roads. Radiator Springs is a fictional village on Route 66, depicted in the 2006 Pixar animated film, Cars with real places along the US Route 66 as the backdrop. It parallels alongside I-10 from Santa Monica to San Bernardino along a variety of roads/state highways (SR-2, SR-110, I-210, SR-66) through Santa Monica, West Hollywood, San Fernando Valley, Pasadena, Asuza, Rancho Cucamonga and San Bernardino in Southern California. From San Bernardino the old Route 66 winds its way north towards Kingman alongside I-15 & 40. The western terminus of Route 66 is on Lincoln Blvd at Olympic Blvd in Santa Monica, at Exit 1 of I-10.
• Space Travel A number of Spaceflight sites, visitor's centers, observatories and other space (travel) related facilities in the United States, such as the Johnson Space Center in Houston, Steward Observatory and Mt Lemon Sky Center in Tucson; Spaceport America in New Mexico; Stennis Space Center in Mississippi, etc. are in the states that are served by I-10. Some can be closer to I-10 while others further away such as the Kennedy Space Center in Florida.
• St Augustine, FL and San Diego, CA are not on Interstate 10 but are the actual end points of the Old Spanish (Auto) Trail from before 1926. The monuments marking the beginning and end of the Old Spanish Trail are at the northeast corner of Huguenot Cemetery, next the Civic Center, in Saint Augustine and at Horton Plaza Park in Gastown/downtown San Diego.
• (Various cities and regions) listed under "Drive" in the above. From these cities one can travel further along another road to another region or into Mexico as I-10 parallels the Mexican border, with El Paso being the closest to Mexico.

Routes through Interstate 10

Lake City ← Osceola National Forest ←	W  E	→ Jacksonville → Ends at in Jacksonville Beach
Lake City ← Osceola Nat'l Forest ←	W  E	→ Jct → Ends at in Jacksonville
Ends at in Van Horn ← Marfa ←	W  E	→ Alpine → Marathon → Del Rio
Ends at in Santa Monica ← Culver City ←	W  E	→ West L.A. → Downtown L.A.